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10.1038/nmeth.3654

http://scihub22266oqcxt.onion/10.1038/nmeth.3654
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C4697868!4697868!26550772
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suck abstract from ncbi


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pmid26550772      Nat+Methods 2016 ; 13 (1): 63-5
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  • Efficient genotype compression and analysis of large genetic variation datasets #MMPMID26550772
  • Layer RM; Kindlon N; Karczewski KJ; Quinlan AR
  • Nat Methods 2016[Jan]; 13 (1): 63-5 PMID26550772show ga
  • Genotype Query Tools (GQT) is a new indexing strategy that expedites analyses of genome variation datasets in VCF format based on sample genotypes, phenotypes and relationships. GQT?s compressed genotype index minimizes decompression for analysis, and performance relative to existing methods improves with cohort size. We show substantial (up to 443 fold) performance gains over existing methods and demonstrate GQT?s utility for exploring massive datasets involving thousands to millions of genomes.
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