Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.neuropharm.2012.06.051 http://scihub22266oqcxt.onion/10.1016/j.neuropharm.2012.06.051 C4696548!4696548!22796429     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=22796429&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 500 Internal Server Error in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neuropharmacology 2013 ; 64 (ä): 13-26 Nephropedia Template TP {{tp|p=22796429|t=2013. The NMDA receptor as a target for cognitive enhancement |pdf=|usr=}}{{22796429}} gab.com Text The NMDA receptor as a target for cognitive enhancement JO: Neuropharmacology http://www.kidney.de/pget.php?&tw=1&pmid=22796429 #FOAvip NMDA receptors (NMDAR) play an important role in neural plasticity including long-term potentiation and long-term depression, which are likely to explain their importance for learning and memory. Cognitive decline is a major problem facing an ageing human population, so much so that its reversal has become an important goal for scientific research and pharmaceutical development. Enhancement of NMDAR function is a core strategy toward this goal. In this review we indicate some of the major ways of potentiating NMDAR function by both direct and indirect modulation. There is good evidence that both positive and negative modulation can enhance function suggesting that a subtle approach correcting imbalances in particular clinical situations will be required. Excessive activation and the resultant deleterious effects will need to be carefully avoided. Finally we describe some novel positive allosteric modulators of NMDARs, with some subunit selectivity, and show initial evidence of their ability to affect NMDAR mediated events. Twit Text FOAVip The NMDA receptor as a target for cognitive enhancement ????Neuropharmacology http://www.kidney.de/pget.php?&tw=1&pmid=22796429 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22796429 #FOAvip English Wikipedia <ref>{{Cite pmid|22796429}}</ref> The NMDA receptor as a target for cognitive enhancement #MMPMID22796429 Collingridge GL; Volianskis A; Bannister N; France G; Hanna L; Mercier M; Tidball P; Fang G; Irvine MW; Costa BM; Monaghan DT; Bortolotto ZA; Molnár E; Lodge D; Jane DE Neuropharmacology 2013[Jan]; 64 (ä): 13-26 PMID22796429show ga NMDA receptors (NMDAR) play an important role in neural plasticity including long-term potentiation and long-term depression, which are likely to explain their importance for learning and memory. Cognitive decline is a major problem facing an ageing human population, so much so that its reversal has become an important goal for scientific research and pharmaceutical development. Enhancement of NMDAR function is a core strategy toward this goal. In this review we indicate some of the major ways of potentiating NMDAR function by both direct and indirect modulation. There is good evidence that both positive and negative modulation can enhance function suggesting that a subtle approach correcting imbalances in particular clinical situations will be required. Excessive activation and the resultant deleterious effects will need to be carefully avoided. Finally we describe some novel positive allosteric modulators of NMDARs, with some subunit selectivity, and show initial evidence of their ability to affect NMDAR mediated events. äThe NMDA receptor as a target for cognitive enhancement (epmc).pdf DeepDyve Pubget Overpricing