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10.1517/17460441.2014.966680 http://scihub22266oqcxt.onion/10.1517/17460441.2014.966680 C4696509!4696509 !25488672     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25488672 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Expert+Opin+Drug+Discov 2015 ; 10 (1 ): 17-36 Nephropedia Template TP {{tp|p=25488672 |t=2015. Drug discovery strategies that focus on the endocannabinoid signaling system in psychiatric disease |pdf=|usr=}}{{25488672 }} gab.com Text Drug discovery strategies that focus on the endocannabinoid signaling system in psychiatric disease JO: Expert Opin Drug Discov http://www.kidney.de/pget.php?&tw=1&pmid=25488672 #FOAvip INTRODUCTION: The endocannabinoid (eCB) system plays an important role in the control of mood, and its dysregulation has been implicated in several psychiatric disorders. Targeting the eCB system appears to represent an attractive and novel approach to the treatment of depression and other mood disorders. However, several failed clinical trials have diminished enthusiasm for the continued development of eCB-targeted therapeutics for psychiatric disorders, despite the encouraging preclinical data and promising preliminary results obtained with the synthetic cannabinoid nabilone for treating post-traumatic stress disorder. AREAS COVERED: This review describes the eCB system's role in modulating cell signaling within the brain. There is a specific focus on eCB's regulation of monoamine neurotransmission and the stress axis, as well as how dysfunction of this interaction can contribute to the development of psychiatric disorders. Additionally, the review provides discussion on compounds and drugs that target this system and might prove to be successful for the treatment of mood-related psychiatric disorders. EXPERT OPINION: The discovery of increasingly selective modulators of CB receptors should enable the identification of optimal therapeutic strategies. It should also maximize the likelihood of developing safe and effective treatments for debilitating psychiatric disorders. Twit Text FOAVip Drug discovery strategies that focus on the endocannabinoid signaling system in psychiatric disease ????Expert Opin Drug Discov http://www.kidney.de/pget.php?&tw=1&pmid=25488672 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25488672 #FOAvip English Wikipedia <ref>{{Cite pmid|25488672 }}</ref> Drug discovery strategies that focus on the endocannabinoid signaling system in psychiatric disease #MMPMID25488672 Wyrofsky R ; McGonigle P ; Van Bockstaele EJ Expert Opin Drug Discov 2015[Jan]; 10 (1 ): 17-36 PMID25488672 show ga INTRODUCTION: The endocannabinoid (eCB) system plays an important role in the control of mood, and its dysregulation has been implicated in several psychiatric disorders. Targeting the eCB system appears to represent an attractive and novel approach to the treatment of depression and other mood disorders. However, several failed clinical trials have diminished enthusiasm for the continued development of eCB-targeted therapeutics for psychiatric disorders, despite the encouraging preclinical data and promising preliminary results obtained with the synthetic cannabinoid nabilone for treating post-traumatic stress disorder. AREAS COVERED: This review describes the eCB system's role in modulating cell signaling within the brain. There is a specific focus on eCB's regulation of monoamine neurotransmission and the stress axis, as well as how dysfunction of this interaction can contribute to the development of psychiatric disorders. Additionally, the review provides discussion on compounds and drugs that target this system and might prove to be successful for the treatment of mood-related psychiatric disorders. EXPERT OPINION: The discovery of increasingly selective modulators of CB receptors should enable the identification of optimal therapeutic strategies. It should also maximize the likelihood of developing safe and effective treatments for debilitating psychiatric disorders. |Affect/drug effects [MESH] |Animals [MESH] |Antipsychotic Agents/chemistry/pharmacology/*therapeutic use [MESH] |Brain/drug effects/metabolism [MESH] |Drug Discovery/*methods [MESH] |Endocannabinoids/*metabolism [MESH] |Humans [MESH] |Mental Disorders/*drug therapy/metabolism/psychology [MESH] |Molecular Structure [MESH] |Receptors, Cannabinoid/metabolism [MESH] |Signal Transduction/*drug effects [MESH]Drug discovery strategies that focus on the endocannabinoid signaling (epmc).pdf DeepDyve Pubget Overpricing