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10.1089/jop.2015.0018

http://scihub22266oqcxt.onion/10.1089/jop.2015.0018
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C4696437!4696437!26352160
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suck abstract from ncbi

pmid26352160      J+Ocul+Pharmacol+Ther 2015 ; 31 (7): 366-70
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  • Thrombospondin-1-Based Antiangiogenic Therapy #MMPMID26352160
  • Sims JN; Lawler J
  • J Ocul Pharmacol Ther 2015[Sep]; 31 (7): 366-70 PMID26352160show ga
  • Ocular angiogenesis is one of the underlying causes of blindness and vision impairment and may occur in a spectrum of disorders, including diabetic retinopathy, neovascular age-related macular degeneration, retinal artery or vein occlusion, and retinopathy of prematurity. As such, strategies to inhibit angiogenesis by suppressing vascular endothelial growth factor activity have proven to be effective in the clinic for the treatment of eye diseases. A complementary approach would be to increase the level of naturally occurring inhibitors of angiogenesis, such as thrombospondin (TSP)-1. This article summarizes the development of TSP-1-based inhibitors of angiogenesis.
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