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10.1186/s13015-015-0061-5 http://scihub22266oqcxt.onion/10.1186/s13015-015-0061-5 C4696214!4696214!26719759     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Algorithms+Mol+Biol 2015 ; 10 (ä): ä Nephropedia Template TP {{tp|p=26719759|t=2015. Interpretation and approximation tools for big, dense Markov chain transition matrices in population genetics |pdf=|usr=}}{{26719759}} gab.com Text Interpretation and approximation tools for big, dense Markov chain transition matrices in population genetics JO: Algorithms Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=26719759 #FOAvip Background: Markov chains are a common framework for individual-based state and time discrete models in evolution. Though they played an important role in the development of basic population genetic theory, the analysis of more complex evolutionary scenarios typically involves approximation with other types of models. As the number of states increases, the big, dense transition matrices involved become increasingly unwieldy. However, advances in computational technology continue to reduce the challenges of ?big data?, thus giving new potential to state-rich Markov chains in theoretical population genetics. Results: Using a population genetic model based on genotype frequencies as an example, we propose a set of methods to assist in the computation and interpretation of big, dense Markov chain transition matrices. With the help of network analysis, we demonstrate how they can be transformed into clear and easily interpretable graphs, providing a new perspective even on the classic case of a randomly mating, finite population with mutation. Moreover, we describe an algorithm to save computer memory by substituting the original matrix with a sparse approximate while preserving its mathematically important properties, including a closely corresponding dominant (normalized) eigenvector. A global sensitivity analysis of the approximation results in our example shows that size reduction of more than 90 % is possible without significantly affecting the basic model results. Sample implementations of our methods are collected in the Python module mamoth. Conclusion: Our methods help to make stochastic population genetic models involving big, dense transition matrices computationally feasible. Our visualization techniques provide new ways to explore such models and concisely present the results. Thus, our methods will contribute to establish state-rich Markov chains as a valuable supplement to the diversity of population genetic models currently employed, providing interesting new details about evolution e.g. under non-standard reproductive systems such as partial clonality. Electronic supplementary material: The online version of this article (doi:10.1186/s13015-015-0061-5) contains supplementary material, which is available to authorized users. Twit Text FOAVip Interpretation and approximation tools for big, dense Markov chain transition matrices in population genetics ????Algorithms Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=26719759 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26719759 #FOAvip English Wikipedia <ref>{{Cite pmid|26719759}}</ref> Interpretation and approximation tools for big, dense Markov chain transition matrices in population genetics #MMPMID26719759 Reichel K; Bahier V; Midoux C; Parisey N; Masson JP; Stoeckel S Algorithms Mol Biol 2015[]; 10 (ä): ä PMID26719759show ga Background: Markov chains are a common framework for individual-based state and time discrete models in evolution. Though they played an important role in the development of basic population genetic theory, the analysis of more complex evolutionary scenarios typically involves approximation with other types of models. As the number of states increases, the big, dense transition matrices involved become increasingly unwieldy. However, advances in computational technology continue to reduce the challenges of ?big data?, thus giving new potential to state-rich Markov chains in theoretical population genetics. Results: Using a population genetic model based on genotype frequencies as an example, we propose a set of methods to assist in the computation and interpretation of big, dense Markov chain transition matrices. With the help of network analysis, we demonstrate how they can be transformed into clear and easily interpretable graphs, providing a new perspective even on the classic case of a randomly mating, finite population with mutation. Moreover, we describe an algorithm to save computer memory by substituting the original matrix with a sparse approximate while preserving its mathematically important properties, including a closely corresponding dominant (normalized) eigenvector. A global sensitivity analysis of the approximation results in our example shows that size reduction of more than 90 % is possible without significantly affecting the basic model results. Sample implementations of our methods are collected in the Python module mamoth. Conclusion: Our methods help to make stochastic population genetic models involving big, dense transition matrices computationally feasible. Our visualization techniques provide new ways to explore such models and concisely present the results. Thus, our methods will contribute to establish state-rich Markov chains as a valuable supplement to the diversity of population genetic models currently employed, providing interesting new details about evolution e.g. under non-standard reproductive systems such as partial clonality. Electronic supplementary material: The online version of this article (doi:10.1186/s13015-015-0061-5) contains supplementary material, which is available to authorized users. äInterpretation and approximation tools for big, dense Markov chain tra(epmc).pdf DeepDyve Pubget Overpricing