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FRMD3 gene: its role in diabetic kidney disease A narrative review #MMPMID26719775
Buffon MP; Sortica DA; Gerchman F; Crispim D; Canani LH
Diabetol Metab Syndr 2015[]; 7 (ä): ä PMID26719775show ga
Diabetic kidney disease (DKD) is a chronic complication of diabetes mellitus, which is considered a worldwide epidemic. Several studies have been developed in order to elucidate possible genetic factors involved in this disease. The FRMD3 gene, a strong candidate selected from genome wide association studies (GWAS), encodes the structural protein 4.1O involved in maintaining cell shape and integrity. Some single nucleotide polymorphisms (SNPs) located in FRMD3 have been associated with DKD in different ethnicities. However, despite these findings, the matter is still controversial. The aim of this narrative review is to summarize the evidence regarding the role of FRMD3 in DKD.