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10.1186/s12878-015-0040-6 http://scihub22266oqcxt.onion/10.1186/s12878-015-0040-6 C4696138!4696138!26719803     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMC+Hematol 2015 ; 15 (ä): ä Nephropedia Template TP {{tp|p=26719803|t=2015. Gum Arabic as fetal hemoglobin inducing agent in sickle cell anemia; in vivo study |pdf=|usr=}}{{26719803}} gab.com Text Gum Arabic as fetal hemoglobin inducing agent in sickle cell anemia; in vivo study JO: BMC Hematol http://www.kidney.de/pget.php?&tw=1&pmid=26719803 #FOAvip Background: High levels of fetal haemoglobin (HbF) decrease sickle cell anaemia (SCA) severity and leads to improved survival. According to in vivo and in vitro studies, butyrate increases HbF production. Its utilization in clinical practice is hampered, however, by its short half-life. Serum butyrate concentrations could be enhanced by colonic bacterial fermentation of Gum Arabic (GA), edible, dried, gummy exudates from Acacia Senegal tree. We hypothesized that regular intake of GA increases serum butyrate levels, thus inducing HbF production and ameliorating symptoms of sickle cell anemia. Methods: Fourty seven patients (5?42 years) carrying hemoglobin SS were recruited from April 2014 to January 2015. Patients received 30 g/day GA for 12 weeks. HbF, blood count and erythropoietin level were measured. The main outcome of interest was the level of HbF after 12 weeks. The secondary outcomes were improvement in clinical and laboratory results. The study was ethically approved by Alneelain University IRB. Results: The study revealed significant increase in HbF level P.V0.000 [95 % CI, 0.43?1.02], MCV P.V:000 [95 % CI, 2.312?6.058] and Hematocrit level P.V:0.026 [95 % CI, 0.124?1.902]. No significant difference was encountered in platelets count P.V: 0.346 [95 % CI,?25.76?71.94], and WBCs count P.V:0.194 [95 % CI,?8.035?1.68]. Thirty seven percent of patients experienced minor side effects which resolved within a week. Conclusion: These findings reveal a novel effect of GA, which may be used to foster fetal hemoglobin production. Trial registration: ClinicalTrials.gov Identifier: NCT02467257. Registered 3rd June 2015. Electronic supplementary material: The online version of this article (doi:10.1186/s12878-015-0040-6) contains supplementary material, which is available to authorized users. Twit Text FOAVip Gum Arabic as fetal hemoglobin inducing agent in sickle cell anemia; in vivo study ????BMC Hematol http://www.kidney.de/pget.php?&tw=1&pmid=26719803 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26719803 #FOAvip English Wikipedia <ref>{{Cite pmid|26719803}}</ref> Gum Arabic as fetal hemoglobin inducing agent in sickle cell anemia; in vivo study #MMPMID26719803 Kaddam L; FdleAlmula I; Eisawi OA; Abdelrazig HA; Elnimeiri M; Lang F; Saeed AM BMC Hematol 2015[]; 15 (ä): ä PMID26719803show ga Background: High levels of fetal haemoglobin (HbF) decrease sickle cell anaemia (SCA) severity and leads to improved survival. According to in vivo and in vitro studies, butyrate increases HbF production. Its utilization in clinical practice is hampered, however, by its short half-life. Serum butyrate concentrations could be enhanced by colonic bacterial fermentation of Gum Arabic (GA), edible, dried, gummy exudates from Acacia Senegal tree. We hypothesized that regular intake of GA increases serum butyrate levels, thus inducing HbF production and ameliorating symptoms of sickle cell anemia. Methods: Fourty seven patients (5?42 years) carrying hemoglobin SS were recruited from April 2014 to January 2015. Patients received 30 g/day GA for 12 weeks. HbF, blood count and erythropoietin level were measured. The main outcome of interest was the level of HbF after 12 weeks. The secondary outcomes were improvement in clinical and laboratory results. The study was ethically approved by Alneelain University IRB. Results: The study revealed significant increase in HbF level P.V0.000 [95 % CI, 0.43?1.02], MCV P.V:000 [95 % CI, 2.312?6.058] and Hematocrit level P.V:0.026 [95 % CI, 0.124?1.902]. No significant difference was encountered in platelets count P.V: 0.346 [95 % CI,?25.76?71.94], and WBCs count P.V:0.194 [95 % CI,?8.035?1.68]. Thirty seven percent of patients experienced minor side effects which resolved within a week. Conclusion: These findings reveal a novel effect of GA, which may be used to foster fetal hemoglobin production. Trial registration: ClinicalTrials.gov Identifier: NCT02467257. Registered 3rd June 2015. Electronic supplementary material: The online version of this article (doi:10.1186/s12878-015-0040-6) contains supplementary material, which is available to authorized users. äGum Arabic as fetal hemoglobin inducing agent in sickle cell anemia; i(epmc).pdf DeepDyve Pubget Overpricing