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10.1038/nrurol.2014.278 http://scihub22266oqcxt.onion/10.1038/nrurol.2014.278 C4696116!4696116!25311680     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Rev+Urol 2014 ; 11 (11): 622-8 Nephropedia Template TP {{tp|p=25311680|t=2014. Understanding and targeting the Rho kinase pathway in erectile dysfunction |pdf=|usr=}}{{25311680}} gab.com Text Understanding and targeting the Rho kinase pathway in erectile dysfunction JO: Nat Rev Urol http://www.kidney.de/pget.php?&tw=1&pmid=25311680 #FOAvip Erectile dysfunction (ED) is a common disorder that affects a quarter of US men, and has many causes, including endothelial impairment, low testosterone levels, prior surgical manipulation, and/or psychogenic components. Penile erection is a complex process requiring neurally mediated relaxation of arteriolar smooth muscle and engorgement of cavernosal tissues, mediated by nitric oxide (NO). Current medical therapies for ED largely seek to maximize endogenous NO signalling. Certain aetiologies, including diabetes, are difficult to treat with current modalities, emphasizing the need for new molecular targets. Research has demonstrated the importance of RhoA?Rho-associated protein kinase (ROCK) signalling in maintaining a flaccid penile state, and inhibition of RhoA?ROCK signalling potentiates smooth-muscle relaxation in an NO-independent manner. The mechanisms and effects of RhoA?ROCK signalling and inhibition suggest that the RhoA?ROCK pathway could prove to be a new therapeutic target for the treatment of ED. Twit Text FOAVip Understanding and targeting the Rho kinase pathway in erectile dysfunction ????Nat Rev Urol http://www.kidney.de/pget.php?&tw=1&pmid=25311680 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25311680 #FOAvip English Wikipedia <ref>{{Cite pmid|25311680}}</ref> Understanding and targeting the Rho kinase pathway in erectile dysfunction #MMPMID25311680 Sopko NA; Hannan JL; Bivalacqua TJ Nat Rev Urol 2014[Nov]; 11 (11): 622-8 PMID25311680show ga Erectile dysfunction (ED) is a common disorder that affects a quarter of US men, and has many causes, including endothelial impairment, low testosterone levels, prior surgical manipulation, and/or psychogenic components. Penile erection is a complex process requiring neurally mediated relaxation of arteriolar smooth muscle and engorgement of cavernosal tissues, mediated by nitric oxide (NO). Current medical therapies for ED largely seek to maximize endogenous NO signalling. Certain aetiologies, including diabetes, are difficult to treat with current modalities, emphasizing the need for new molecular targets. Research has demonstrated the importance of RhoA?Rho-associated protein kinase (ROCK) signalling in maintaining a flaccid penile state, and inhibition of RhoA?ROCK signalling potentiates smooth-muscle relaxation in an NO-independent manner. The mechanisms and effects of RhoA?ROCK signalling and inhibition suggest that the RhoA?ROCK pathway could prove to be a new therapeutic target for the treatment of ED. äUnderstanding and targeting the Rho kinase pathway in erectile dysfunc(epmc).pdf DeepDyve Pubget Overpricing