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10.1126/scisignal.2005500 http://scihub22266oqcxt.onion/10.1126/scisignal.2005500 C4693296!4693296!25406379     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Signal 2014 ; 7 (352): ra111 Nephropedia Template TP {{tp|p=25406379|t=2014. Characterization of a set of tumor suppressor microRNAs in T cell acute lymphoblastic leukemia |pdf=|usr=}}{{25406379}} gab.com Text Characterization of a set of tumor suppressor microRNAs in T cell acute lymphoblastic leukemia JO: Sci Signal http://www.kidney.de/pget.php?&tw=1&pmid=25406379 #FOAvip The posttranscriptional control of gene expression by microRNAs (miRNAs) is highly redundant, and compensatory effects limit the consequences of the inactivation of individual miRNAs. This implies that only a few miRNAs can function as effective tumor suppressors. It is also the basis of our strategy to define functionally relevant miRNA target genes that are not under redundant control by other miRNAs. We identified a functionally interconnected group of miRNAs that exhibited a reduced abundance in leukemia cells from patients with T cell acute lymphoblastic leukemia (T-ALL). To pinpoint relevant target genes, we applied a machine learning approach to eliminate genes that were subject to redundant miRNA-mediated control and to identify those genes that were exclusively targeted by tumor-suppressive miRNAs. This strategy revealed the convergence of a small group of tumor suppressor miRNAs on the Myb oncogene, as well as their effects on HBP1, which encodes a transcription factor. The expression of both genes was increased in T-ALL patient samples, and each gene promoted the progression of T-ALL in mice. Hence, our systematic analysis of tumor suppressor miRNA action identified a widespread mechanism of oncogene activation in T-ALL. Twit Text FOAVip Characterization of a set of tumor suppressor microRNAs in T cell acute lymphoblastic leukemia ????Sci Signal http://www.kidney.de/pget.php?&tw=1&pmid=25406379 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25406379 #FOAvip English Wikipedia <ref>{{Cite pmid|25406379}}</ref> Characterization of a set of tumor suppressor microRNAs in T cell acute lymphoblastic leukemia #MMPMID25406379 Sanghvi VR; Mavrakis KJ; Van der Meulen J; Boice M; Wolfe AL; Carty M; Mohan P; Rondou P; Socci ND; Benoit Y; Taghon T; Van Vlierberghe P; Leslie CS; Speleman F; Wendel HG Sci Signal 2014[Nov]; 7 (352): ra111 PMID25406379show ga The posttranscriptional control of gene expression by microRNAs (miRNAs) is highly redundant, and compensatory effects limit the consequences of the inactivation of individual miRNAs. This implies that only a few miRNAs can function as effective tumor suppressors. It is also the basis of our strategy to define functionally relevant miRNA target genes that are not under redundant control by other miRNAs. We identified a functionally interconnected group of miRNAs that exhibited a reduced abundance in leukemia cells from patients with T cell acute lymphoblastic leukemia (T-ALL). To pinpoint relevant target genes, we applied a machine learning approach to eliminate genes that were subject to redundant miRNA-mediated control and to identify those genes that were exclusively targeted by tumor-suppressive miRNAs. This strategy revealed the convergence of a small group of tumor suppressor miRNAs on the Myb oncogene, as well as their effects on HBP1, which encodes a transcription factor. The expression of both genes was increased in T-ALL patient samples, and each gene promoted the progression of T-ALL in mice. Hence, our systematic analysis of tumor suppressor miRNA action identified a widespread mechanism of oncogene activation in T-ALL. äCharacterization of a set of tumor suppressor microRNAs in T cell acut(epmc).pdf DeepDyve Pubget Overpricing