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10.1038/nm.3934 http://scihub22266oqcxt.onion/10.1038/nm.3934 C4692717!4692717 !26301690     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26301690 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Med 2015 ; 21 (9 ): 1028-1037 Nephropedia Template TP {{tp|p=26301690 |t=2015. Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure |pdf=|usr=}}{{26301690 }} gab.com Text Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure JO: Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=26301690 #FOAvip Endothelial dysfunction is a critical factor in many cardiovascular diseases, including hypertension. Although lipid signaling has been implicated in endothelial dysfunction and cardiovascular disease, specific molecular mechanisms are poorly understood. Here we report that Nogo-B, a membrane protein of the endoplasmic reticulum, regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Nogo-B inhibits serine palmitoyltransferase, the rate-limiting enzyme of the de novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine 1-phosphate and autocrine, G protein-coupled receptor-dependent signaling by this metabolite. Mice lacking Nogo-B either systemically or specifically in endothelial cells are hypotensive, resistant to angiotensin II-induced hypertension and have preserved endothelial function and nitric oxide release. In mice that lack Nogo-B, pharmacological inhibition of serine palmitoyltransferase with myriocin reinstates endothelial dysfunction and angiotensin II-induced hypertension. Our study identifies Nogo-B as a key inhibitor of local sphingolipid synthesis and shows that autocrine sphingolipid signaling within the endothelium is critical for vascular function and blood pressure homeostasis. Twit Text FOAVip Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure ????Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=26301690 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26301690 #FOAvip English Wikipedia <ref>{{Cite pmid|26301690 }}</ref> Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure #MMPMID26301690 Cantalupo A ; Zhang Y ; Kothiya M ; Galvani S ; Obinata H ; Bucci M ; Giordano FJ ; Jiang XC ; Hla T ; Di Lorenzo A Nat Med 2015[Sep]; 21 (9 ): 1028-1037 PMID26301690 show ga Endothelial dysfunction is a critical factor in many cardiovascular diseases, including hypertension. Although lipid signaling has been implicated in endothelial dysfunction and cardiovascular disease, specific molecular mechanisms are poorly understood. Here we report that Nogo-B, a membrane protein of the endoplasmic reticulum, regulates endothelial sphingolipid biosynthesis with direct effects on vascular function and blood pressure. Nogo-B inhibits serine palmitoyltransferase, the rate-limiting enzyme of the de novo sphingolipid biosynthetic pathway, thereby controlling production of endothelial sphingosine 1-phosphate and autocrine, G protein-coupled receptor-dependent signaling by this metabolite. Mice lacking Nogo-B either systemically or specifically in endothelial cells are hypotensive, resistant to angiotensin II-induced hypertension and have preserved endothelial function and nitric oxide release. In mice that lack Nogo-B, pharmacological inhibition of serine palmitoyltransferase with myriocin reinstates endothelial dysfunction and angiotensin II-induced hypertension. Our study identifies Nogo-B as a key inhibitor of local sphingolipid synthesis and shows that autocrine sphingolipid signaling within the endothelium is critical for vascular function and blood pressure homeostasis. |*Blood Pressure [MESH] |*Homeostasis [MESH] |Animals [MESH] |COS Cells [MESH] |Chlorocebus aethiops [MESH] |Endothelium, Vascular/*physiology [MESH] |HEK293 Cells [MESH] |Humans [MESH] |Lysophospholipids/physiology [MESH] |Male [MESH] |Mice [MESH] |Myelin Proteins/*physiology [MESH] |Nitric Oxide Synthase Type III/physiology [MESH] |Nogo Proteins [MESH] |Receptors, Lysosphingolipid/physiology [MESH] |Sphingolipids/*metabolism [MESH]Nogo-B regulates endothelial sphingolipid homeostasis to control vascu(epmc).pdf DeepDyve Pubget Overpricing