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10.1101/gad.265116.115

http://scihub22266oqcxt.onion/10.1101/gad.265116.115
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C4691891!4691891!26588989
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suck abstract from ncbi


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pmid26588989      Genes+Dev 2015 ; 29 (22): 2362-76
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  • NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition #MMPMID26588989
  • Yuan HX; Wang Z; Yu FX; Li F; Russell RC; Jewell JL; Guan KL
  • Genes Dev 2015[Nov]; 29 (22): 2362-76 PMID26588989show ga
  • Yuan et al. show that the Nemo-like kinase (NLK) phosphorylates Raptor on S863 to disrupt its interaction with the Rag GTPase, which is important for mTORC1 lysosomal recruitment. Cells with Nlk deletion or knock-in of the Raptor S863 phosphorylation mutants are defective in the rapid mTORC1 inhibition upon osmotic stress.
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