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10.1038/nsmb.2879 http://scihub22266oqcxt.onion/10.1038/nsmb.2879 C4691850!4691850!25192263     free     free     free       Nat+Struct+Mol+Biol 2014 ; 21 (9): 743-53 Nephropedia Template TP {{tp|p=25192263|t=2014. The evolutionary journey of Argonaute proteins |pdf=|usr=}}{{25192263}} gab.com Text The evolutionary journey of Argonaute proteins JO: Nat Struct Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=25192263 #FOAvip Argonaute proteins are conserved throughout all domains of life. Recently characterized prokaryotic Argonaute proteins (pAgos) participate in host defense by DNA interference, whereas eukaryotic Argonaute proteins (eAgos) control a wide range of processes by RNA interference. Here we review molecular mechanisms of guide and target binding by Argonaute proteins, and describe how the conformational changes induced by target binding lead to target cleavage. On the basis of structural comparisons and phylogenetic analyses of pAgos and eAgos, we reconstruct the evolutionary journey of the Argonaute proteins through the three domains of life and discuss how different structural features of pAgos and eAgos relate to their distinct physiological roles. Twit Text FOAVip The evolutionary journey of Argonaute proteins ????Nat Struct Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=25192263 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25192263 #FOAvip English Wikipedia <ref>{{Cite pmid|25192263}}</ref> The evolutionary journey of Argonaute proteins #MMPMID25192263 Swarts DC; Makarova K; Wang Y; Nakanishi K; Ketting RF; Koonin EV; Patel DJ; van der Oost J Nat Struct Mol Biol 2014[Sep]; 21 (9): 743-53 PMID25192263show ga Argonaute proteins are conserved throughout all domains of life. Recently characterized prokaryotic Argonaute proteins (pAgos) participate in host defense by DNA interference, whereas eukaryotic Argonaute proteins (eAgos) control a wide range of processes by RNA interference. Here we review molecular mechanisms of guide and target binding by Argonaute proteins, and describe how the conformational changes induced by target binding lead to target cleavage. On the basis of structural comparisons and phylogenetic analyses of pAgos and eAgos, we reconstruct the evolutionary journey of the Argonaute proteins through the three domains of life and discuss how different structural features of pAgos and eAgos relate to their distinct physiological roles. äThe evolutionary journey of Argonaute proteins (epmc).pdf DeepDyve Pubget Overpricing