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10.1126/science.aac7442 http://scihub22266oqcxt.onion/10.1126/science.aac7442 C4691329!4691329!26382853     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2015 ; 350 (6259): 455-9 Nephropedia Template TP {{tp|p=26382853|t=2015. The Ro60 Autoantigen Binds Endogenous Retroelements and Regulates Inflammatory Gene Expression |pdf=|usr=}}{{26382853}} gab.com Text The Ro60 Autoantigen Binds Endogenous Retroelements and Regulates Inflammatory Gene Expression JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=26382853 #FOAvip Autoantibodies target the RNA binding protein Ro60 in systemic lupus erythematosus (SLE) and Sjögren?s syndrome. However, whether Ro60 and its associated RNAs contribute to disease pathogenesis is unclear. We catalogued the Ro60-associated RNAs in human cell lines and found that among other RNAs, Ro60 bound an RNA motif derived from endogenous Alu retroelements. Alu transcripts were induced by type I interferon and stimulated proinflammatory cytokine secretion by human peripheral blood cells. Ro60 deletion resulted in enhanced expression of Alu RNAs and interferon-regulated genes. Anti-Ro60 positive SLE immune complexes contained Alu RNAs, and Alu transcripts were upregulated in SLE whole blood samples compared to controls. These findings establish a link between the lupus autoantigen Ro60, Alu retroelements and type I interferon. Twit Text FOAVip The Ro60 Autoantigen Binds Endogenous Retroelements and Regulates Inflammatory Gene Expression ????Science http://www.kidney.de/pget.php?&tw=1&pmid=26382853 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26382853 #FOAvip English Wikipedia <ref>{{Cite pmid|26382853}}</ref> The Ro60 Autoantigen Binds Endogenous Retroelements and Regulates Inflammatory Gene Expression #MMPMID26382853 Hung T; Pratt G; Sundararaman B; Townsend MJ; Chaivorapol C; Bhangale T; Graham RR; Ortmann W; Criswell LA; Yeo G; Behrens TW Science 2015[Oct]; 350 (6259): 455-9 PMID26382853show ga Autoantibodies target the RNA binding protein Ro60 in systemic lupus erythematosus (SLE) and Sjögren?s syndrome. However, whether Ro60 and its associated RNAs contribute to disease pathogenesis is unclear. We catalogued the Ro60-associated RNAs in human cell lines and found that among other RNAs, Ro60 bound an RNA motif derived from endogenous Alu retroelements. Alu transcripts were induced by type I interferon and stimulated proinflammatory cytokine secretion by human peripheral blood cells. Ro60 deletion resulted in enhanced expression of Alu RNAs and interferon-regulated genes. Anti-Ro60 positive SLE immune complexes contained Alu RNAs, and Alu transcripts were upregulated in SLE whole blood samples compared to controls. These findings establish a link between the lupus autoantigen Ro60, Alu retroelements and type I interferon. äThe Ro60 Autoantigen Binds Endogenous Retroelements and Regulates Infl(epmc).pdf DeepDyve Pubget Overpricing