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10.1038/ni.3296 http://scihub22266oqcxt.onion/10.1038/ni.3296 C4690472!4690472!26502404     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2015 ; 16 (12): 1245-52 Nephropedia Template TP {{tp|p=26502404|t=2015. A map of sphingosine 1-phosphate distribution in the spleen |pdf=|usr=}}{{26502404}} gab.com Text A map of sphingosine 1-phosphate distribution in the spleen JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26502404 #FOAvip Despite the importance of signaling lipids, many questions remain about their function because we have few tools to chart lipid gradients in vivo. Here we describe a sphingosine 1-phosphate (S1P) reporter mouse, and use this mouse to define S1P distribution in the spleen. Surprisingly, the presence of blood does not predict the concentration of signaling-available S1P. Large areas of the red pulp are S1P-low, while S1P can be sensed by cells inside the white pulp near the marginal sinus. Lipid phosphate phosphatase 3 maintains low S1P concentrations in the spleen, and enables efficient marginal zone B cell shuttling. The exquisitely tight regulation of S1P availability may explain how a single lipid can simultaneously orchestrate many immune cell movements. Twit Text FOAVip A map of sphingosine 1-phosphate distribution in the spleen ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26502404 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26502404 #FOAvip English Wikipedia <ref>{{Cite pmid|26502404}}</ref> A map of sphingosine 1-phosphate distribution in the spleen #MMPMID26502404 Ramos-Perez WD; Fang V; Escalante-Alcalde D; Cammer M; Schwab SR Nat Immunol 2015[Dec]; 16 (12): 1245-52 PMID26502404show ga Despite the importance of signaling lipids, many questions remain about their function because we have few tools to chart lipid gradients in vivo. Here we describe a sphingosine 1-phosphate (S1P) reporter mouse, and use this mouse to define S1P distribution in the spleen. Surprisingly, the presence of blood does not predict the concentration of signaling-available S1P. Large areas of the red pulp are S1P-low, while S1P can be sensed by cells inside the white pulp near the marginal sinus. Lipid phosphate phosphatase 3 maintains low S1P concentrations in the spleen, and enables efficient marginal zone B cell shuttling. The exquisitely tight regulation of S1P availability may explain how a single lipid can simultaneously orchestrate many immune cell movements. äA map of sphingosine 1-phosphate distribution in the spleen (epmc).pdf DeepDyve Pubget Overpricing