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10.1186/s13578-015-0052-8 http://scihub22266oqcxt.onion/10.1186/s13578-015-0052-8 C4690337!4690337!26705467     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Biosci 2015 ; 5 (ä): ä Nephropedia Template TP {{tp|p=26705467|t=2015. Complement C4 induces regulatory T cells differentiation through dendritic cell in systemic lupus erythematosus |pdf=|usr=}}{{26705467}} gab.com Text Complement C4 induces regulatory T cells differentiation through dendritic cell in systemic lupus erythematosus JO: Cell Biosci http://www.kidney.de/pget.php?&tw=1&pmid=26705467 #FOAvip Background: Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disease. Complement component 4 (C4) has be proved to play a role in pathogenesis of SLE. In the present study, we investigated the effect of C4 on T cells differentiation. Methods: Thirty SLE patients were included in this study. CD4+ T cells were isolated from healthy subjects, and dendritic cells (DCs) were isolated from healthy subjects or SLE patients. C4 was supplemented to co-incubate with T cells and DCs. Results: Serum C4 concentration was positively correlated with regulatory T cell (Treg) percentage (R2 = 0.5907, p < 0.001) and TGF? concentration (R2 = 0.5641, p < 0.001) in SLE patients. Different concentrations of C4 had no effect on T cells differentiation. Co-incubated T cells with DCs and C4 for 7 days, the Treg percentage and TGF-? concentration were significantly elevated. In addition, pre-treated DCs (from healthy subjects or SLE patients) with C4 and then co-incubated with T cells, the increases of Treg percentage and TGF-? concentration were also observed. Conclusion: C4 takes part in T cells differentiation to Treg cells via DCs. Twit Text FOAVip Complement C4 induces regulatory T cells differentiation through dendritic cell in systemic lupus erythematosus ????Cell Biosci http://www.kidney.de/pget.php?&tw=1&pmid=26705467 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26705467 #FOAvip English Wikipedia <ref>{{Cite pmid|26705467}}</ref> Complement C4 induces regulatory T cells differentiation through dendritic cell in systemic lupus erythematosus #MMPMID26705467 Cheng HB; Chen RY; Wu JP; Chen L; Liang YH; Pan HF; Pan ZF; Zhang QH; Li Q; Du TX; Lv YM; Shi JQ Cell Biosci 2015[]; 5 (ä): ä PMID26705467show ga Background: Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disease. Complement component 4 (C4) has be proved to play a role in pathogenesis of SLE. In the present study, we investigated the effect of C4 on T cells differentiation. Methods: Thirty SLE patients were included in this study. CD4+ T cells were isolated from healthy subjects, and dendritic cells (DCs) were isolated from healthy subjects or SLE patients. C4 was supplemented to co-incubate with T cells and DCs. Results: Serum C4 concentration was positively correlated with regulatory T cell (Treg) percentage (R2 = 0.5907, p < 0.001) and TGF? concentration (R2 = 0.5641, p < 0.001) in SLE patients. Different concentrations of C4 had no effect on T cells differentiation. Co-incubated T cells with DCs and C4 for 7 days, the Treg percentage and TGF-? concentration were significantly elevated. In addition, pre-treated DCs (from healthy subjects or SLE patients) with C4 and then co-incubated with T cells, the increases of Treg percentage and TGF-? concentration were also observed. Conclusion: C4 takes part in T cells differentiation to Treg cells via DCs. äComplement C4 induces regulatory T cells differentiation through dendr(epmc).pdf DeepDyve Pubget Overpricing