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10.1186/s13578-015-0052-8 http://scihub22266oqcxt.onion/10.1186/s13578-015-0052-8 C4690337!4690337 !26705467     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26705467 &cmd=llinks): Failed to open stream: HTTP request failed! 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Complement C4 induces regulatory T cells differentiation through dendritic cell in systemic lupus erythematosus |pdf=|usr=}}{{26705467 }} gab.com Text Complement C4 induces regulatory T cells differentiation through dendritic cell in systemic lupus erythematosus JO: Cell Biosci http://www.kidney.de/pget.php?&tw=1&pmid=26705467 #FOAvip BACKGROUND: Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disease. Complement component 4 (C4) has be proved to play a role in pathogenesis of SLE. In the present study, we investigated the effect of C4 on T cells differentiation. METHODS: Thirty SLE patients were included in this study. CD4+ T cells were isolated from healthy subjects, and dendritic cells (DCs) were isolated from healthy subjects or SLE patients. C4 was supplemented to co-incubate with T cells and DCs. RESULTS: Serum C4 concentration was positively correlated with regulatory T cell (Treg) percentage (R(2) = 0.5907, p < 0.001) and TGF? concentration (R(2) = 0.5641, p < 0.001) in SLE patients. Different concentrations of C4 had no effect on T cells differentiation. Co-incubated T cells with DCs and C4 for 7 days, the Treg percentage and TGF-? concentration were significantly elevated. In addition, pre-treated DCs (from healthy subjects or SLE patients) with C4 and then co-incubated with T cells, the increases of Treg percentage and TGF-? concentration were also observed. CONCLUSION: C4 takes part in T cells differentiation to Treg cells via DCs. Twit Text FOAVip Complement C4 induces regulatory T cells differentiation through dendritic cell in systemic lupus erythematosus ????Cell Biosci http://www.kidney.de/pget.php?&tw=1&pmid=26705467 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26705467 #FOAvip English Wikipedia <ref>{{Cite pmid|26705467 }}</ref> Complement C4 induces regulatory T cells differentiation through dendritic cell in systemic lupus erythematosus #MMPMID26705467 Cheng HB ; Chen RY ; Wu JP ; Chen L ; Liang YH ; Pan HF ; Pan ZF ; Zhang QH ; Li Q ; Du TX ; Lv YM ; Shi JQ Cell Biosci 2015[]; 5 (ä): 73 PMID26705467 show ga BACKGROUND: Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disease. Complement component 4 (C4) has be proved to play a role in pathogenesis of SLE. In the present study, we investigated the effect of C4 on T cells differentiation. METHODS: Thirty SLE patients were included in this study. CD4+ T cells were isolated from healthy subjects, and dendritic cells (DCs) were isolated from healthy subjects or SLE patients. C4 was supplemented to co-incubate with T cells and DCs. RESULTS: Serum C4 concentration was positively correlated with regulatory T cell (Treg) percentage (R(2) = 0.5907, p < 0.001) and TGF? concentration (R(2) = 0.5641, p < 0.001) in SLE patients. Different concentrations of C4 had no effect on T cells differentiation. Co-incubated T cells with DCs and C4 for 7 days, the Treg percentage and TGF-? concentration were significantly elevated. In addition, pre-treated DCs (from healthy subjects or SLE patients) with C4 and then co-incubated with T cells, the increases of Treg percentage and TGF-? concentration were also observed. CONCLUSION: C4 takes part in T cells differentiation to Treg cells via DCs. äComplement C4 induces regulatory T cells differentiation through dendr(epmc).pdf DeepDyve Pubget Overpricing