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10.3390/genes6041183 http://scihub22266oqcxt.onion/10.3390/genes6041183 C4690034!4690034!26569311     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Genes+(Basel) 2015 ; 6 (4): 1183-200 Nephropedia Template TP {{tp|p=26569311|t=2015. Super Enhancers in Cancers, Complex Disease, and Developmental Disorders |pdf=|usr=}}{{26569311}} gab.com Text Super Enhancers in Cancers, Complex Disease, and Developmental Disorders JO: Genes (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=26569311 #FOAvip Recently, unique areas of transcriptional regulation termed super-enhancers have been identified and implicated in human disease. Defined by their magnitude of size, transcription factor density, and binding of transcriptional machinery, super-enhancers have been associated with genes driving cell differentiation. While their functions are not completely understood, it is clear that these regions driving high-level transcription are susceptible to perturbation, and trait-associated single nucleotide polymorphisms (SNPs) occur within super-enhancers of disease-relevant cell types. Here we review evidence for super-enhancer involvement in cancers, complex diseases, and developmental disorders and discuss interactions between super-enhancers and cofactors/chromatin regulators. Twit Text FOAVip Super Enhancers in Cancers, Complex Disease, and Developmental Disorders ????Genes (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=26569311 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26569311 #FOAvip English Wikipedia <ref>{{Cite pmid|26569311}}</ref> Super Enhancers in Cancers, Complex Disease, and Developmental Disorders #MMPMID26569311 Niederriter AR; Varshney A; Parker SCJ; Martin DM Genes (Basel) 2015[Dec]; 6 (4): 1183-200 PMID26569311show ga Recently, unique areas of transcriptional regulation termed super-enhancers have been identified and implicated in human disease. Defined by their magnitude of size, transcription factor density, and binding of transcriptional machinery, super-enhancers have been associated with genes driving cell differentiation. While their functions are not completely understood, it is clear that these regions driving high-level transcription are susceptible to perturbation, and trait-associated single nucleotide polymorphisms (SNPs) occur within super-enhancers of disease-relevant cell types. Here we review evidence for super-enhancer involvement in cancers, complex diseases, and developmental disorders and discuss interactions between super-enhancers and cofactors/chromatin regulators. äSuper Enhancers in Cancers, Complex Disease, and Developmental Disorde(epmc).pdf DeepDyve Pubget Overpricing