Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26722657
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26722657
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 World+J+Transplant
2015 ; 5
(4
): 292-9
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Clinical and pathological features of kidney transplant patients with concurrent
polyomavirus nephropathy and rejection-associated endarteritis
#MMPMID26722657
McGregor SM
; Chon WJ
; Kim L
; Chang A
; Meehan SM
World J Transplant
2015[Dec]; 5
(4
): 292-9
PMID26722657
show ga
AIM: To describe the clinicopathologic features of concurrent polyomavirus
nephropathy (PVN) and endarteritis due to rejection in renal allografts. METHODS:
We searched our electronic records database for cases with transplant kidney
biopsies demonstrating features of both PVN and acute rejection (AR). PVN was
defined by the presence of typical viral cytopathic effect on routine sections
and positive polyomavirus SV40 large-T antigen immunohistochemistry. AR was
identified by endarteritis (v1 by Banff criteria). All cases were subjected to
chart review in order to determine clinical presentation, treatment course and
outcomes. Outcomes were recorded with a length of follow-up of at least one year
or time to nephrectomy. RESULTS: Of 94 renal allograft recipients who developed
PVN over an 11-year period at our institution, we identified 7 (7.4%) with viral
cytopathic changes, SV40 large T antigen staining, and endarteritis in the same
biopsy specimen, indicative of concurrent PVN and AR. Four arose after reduction
of immunosuppression (IS) (for treatment of PVN in 3 and tuberculosis in 1), and
3 patients had no decrease of IS before developing simultaneous concurrent
disease. Treatment consisted of reduced oral IS and leflunomide for PVN, and
anti-rejection therapy. Three of 4 patients who developed endarteritis in the
setting of reduced IS lost their grafts to rejection. All 3 patients with
simultaneous PVN and endarteritis cleared viremia and were stable at 1 year of
follow up. Patients with endarteritis and PVN arising in a background of reduced
IS had more severe rejection and poorer outcome. CONCLUSION: Concurrent PVN and
endarteritis may be more frequent than is currently appreciated and may occur
with or without prior reduction of IS.