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10.5500/wjt.v5.i4.251 http://scihub22266oqcxt.onion/10.5500/wjt.v5.i4.251 C4689935!4689935!26722652     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       World+J+Transplant 2015 ; 5 (4): 251-60 Nephropedia Template TP {{tp|p=26722652|t=2015. Role for urinary biomarkers in diagnosis of acute rejection in the transplanted kidney |pdf=|usr=}}{{26722652}} gab.com Text Role for urinary biomarkers in diagnosis of acute rejection in the transplanted kidney JO: World J Transplant http://www.kidney.de/pget.php?&tw=1&pmid=26722652 #FOAvip Despite the introduction of potent immunosuppressive medications within recent decades, acute rejection still accounts for up to 12% of all graft losses, and is generally associated with an increased risk of late graft failure. Current detection of acute rejection relies on frequent monitoring of the serum creatinine followed by a diagnostic renal biopsy. This strategy is flawed since an alteration in the serum creatinine is a late clinical event and significant irreversible histologic damage has often already occurred. Furthermore, biopsies are invasive procedures that carry their own inherent risk. The discovery of non-invasive urinary biomarkers to help diagnose acute rejection has been the subject of a significant amount of investigation. We review the literature on urinary biomarkers here, focusing on specific markers perforin and granzyme B mRNAs, FOXP3 mRNA, CXCL9/CXCL10 and miRNAs. These and other biomarkers are not yet widely used in clinical settings, but our review of the literature suggests that biomarkers may correlate with biopsy findings and provide an important early indicator of rejection, allowing more rapid treatment and better graft survival. Twit Text FOAVip Role for urinary biomarkers in diagnosis of acute rejection in the transplanted kidney ????World J Transplant http://www.kidney.de/pget.php?&tw=1&pmid=26722652 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26722652 #FOAvip English Wikipedia <ref>{{Cite pmid|26722652}}</ref> Role for urinary biomarkers in diagnosis of acute rejection in the transplanted kidney #MMPMID26722652 Merhi B; Bayliss G; Gohh RY World J Transplant 2015[Dec]; 5 (4): 251-60 PMID26722652show ga Despite the introduction of potent immunosuppressive medications within recent decades, acute rejection still accounts for up to 12% of all graft losses, and is generally associated with an increased risk of late graft failure. Current detection of acute rejection relies on frequent monitoring of the serum creatinine followed by a diagnostic renal biopsy. This strategy is flawed since an alteration in the serum creatinine is a late clinical event and significant irreversible histologic damage has often already occurred. Furthermore, biopsies are invasive procedures that carry their own inherent risk. The discovery of non-invasive urinary biomarkers to help diagnose acute rejection has been the subject of a significant amount of investigation. We review the literature on urinary biomarkers here, focusing on specific markers perforin and granzyme B mRNAs, FOXP3 mRNA, CXCL9/CXCL10 and miRNAs. These and other biomarkers are not yet widely used in clinical settings, but our review of the literature suggests that biomarkers may correlate with biopsy findings and provide an important early indicator of rejection, allowing more rapid treatment and better graft survival. äRole for urinary biomarkers in diagnosis of acute rejection in the tra(epmc).pdf DeepDyve Pubget Overpricing