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10.1007/s12094-015-1435-3 http://scihub22266oqcxt.onion/10.1007/s12094-015-1435-3 C4689749!4689749!26669313     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Transl+Oncol 2015 ; 17 (ä): 956-61 Nephropedia Template TP {{tp|p=26669313|t=2015. SEOM clinical guidelines in Hereditary Breast and ovarian cancer |pdf=|usr=}}{{26669313}} gab.com Text SEOM clinical guidelines in Hereditary Breast and ovarian cancer JO: Clin Transl Oncol http://www.kidney.de/pget.php?&tw=1&pmid=26669313 #FOAvip Approximately, 7 % of all breast cancers (BC) and 11?15 % of ovarian cancers (OC) are associated with inherited predisposition, mainly related to germline mutations in high penetrance BRCA1/2 genes. Clinical criteria for genetic testing are based on personal and family history to estimate a minimum 10 % detection rate. Selection criteria are evolving according to new advances in this field and the clinical utility of genetic testing. Multiplex panel testing carries its own challenges and we recommend inclusion of genes with clinical utility. We recommend screening with annual mammography from age 30 and breast MRI from age 25 for BRCA1 and BRCA2 mutation carriers. Bilateral salpingo-oophorectomy should be offered to women with a BRCA1 or BRCA2 mutation, between 35 and 40 years and after completion of childbearing, or individualise based on the earliest age of ovarian cancer diagnosed in the family. Bilateral risk-reducing mastectomy is an option for healthy BRCA1 and BRCA2 mutation carriers, as well as contralateral mastectomy for young patients with a prior BC diagnosis. BRCA genetic testing in patients with BC and OC may influence their locoregional and systemic treatment. Twit Text FOAVip SEOM clinical guidelines in Hereditary Breast and ovarian cancer ????Clin Transl Oncol http://www.kidney.de/pget.php?&tw=1&pmid=26669313 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26669313 #FOAvip English Wikipedia <ref>{{Cite pmid|26669313}}</ref> SEOM clinical guidelines in Hereditary Breast and ovarian cancer #MMPMID26669313 Llort G; Chirivella I; Morales R; Serrano R; Sanchez AB; Teulé A; Lastra E; Brunet J; Balmaña J; Graña B Clin Transl Oncol 2015[]; 17 (ä): 956-61 PMID26669313show ga Approximately, 7 % of all breast cancers (BC) and 11?15 % of ovarian cancers (OC) are associated with inherited predisposition, mainly related to germline mutations in high penetrance BRCA1/2 genes. Clinical criteria for genetic testing are based on personal and family history to estimate a minimum 10 % detection rate. Selection criteria are evolving according to new advances in this field and the clinical utility of genetic testing. Multiplex panel testing carries its own challenges and we recommend inclusion of genes with clinical utility. We recommend screening with annual mammography from age 30 and breast MRI from age 25 for BRCA1 and BRCA2 mutation carriers. Bilateral salpingo-oophorectomy should be offered to women with a BRCA1 or BRCA2 mutation, between 35 and 40 years and after completion of childbearing, or individualise based on the earliest age of ovarian cancer diagnosed in the family. Bilateral risk-reducing mastectomy is an option for healthy BRCA1 and BRCA2 mutation carriers, as well as contralateral mastectomy for young patients with a prior BC diagnosis. BRCA genetic testing in patients with BC and OC may influence their locoregional and systemic treatment. äSEOM clinical guidelines in Hereditary Breast and ovarian cancer (epmc).pdf DeepDyve Pubget Overpricing