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2015 ; 4
(ä): 806
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Terlipressin and albumin for type 1 hepatorenal syndrome: does bacterial
infection affect the response?
#MMPMID26722626
Altun R
; Korkmaz M
; Y?ld?r?m E
; Öcal S
; Akba? E
; Selçuk H
Springerplus
2015[]; 4
(ä): 806
PMID26722626
show ga
Vasoconstrictor therapy with terlipressin and concomitant albumin can improve
renal function in patients with hepatorenal syndrome (HRS) type 1, but the
efficacy of therapy in patients with active infection is controversial. The aim
of this study was to investigate the efficacy, adverse effects, and predictors of
terlipressin therapy and to find out whether there was a difference in response
rates between the patients with or without active infections. Data of 58 patients
with type 1 HRS treated with terlipressin and albumin were retrospectively
evaluated. Twenty-six patients (44.8 %) showed complete response to treatment.
Response rates of patients with or without active bacterial infection were 47 and
43.9 %, respectively (p > 0.05). Only baseline serum creatinine level was
significantly related to response in univariate/multivariate analyses (p < 0.05).
Twenty-three patients (39.6 %) developed adverse effects probably related to
treatment. In 8.6 % of patients, treatment was discontinued because of adverse
effects of therapy. Four patients (6.9 %) developed ischemic adverse events,
including nonfatal myocardial infarction, intestinal ischemia, and cutaneous
necrosis. Terlipressin plus albumin therapy improved renal function in nearly
half of patients with type 1 HRS. Thus, it seems a reasonable treatment for
patients with active bacterial infections. Baseline serum creatinine level is a
potential predictor of terlipressin response.