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10.1371/journal.pone.0143182 http://scihub22266oqcxt.onion/10.1371/journal.pone.0143182 C4689521!4689521!26699128     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2015 ; 10 (12): ä Nephropedia Template TP {{tp|p=26699128|t=2015. Non-Catalytic RISCs and Kinetics Determine Mammalian siRNA Sub-Cellular Localization |pdf=|usr=}}{{26699128}} gab.com Text Non-Catalytic RISCs and Kinetics Determine Mammalian siRNA Sub-Cellular Localization JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26699128 #FOAvip Small interfering RNAs (siRNAs) are fundamental to the regulation of cell function. Much is known about its gene interfering mechanism, but a kinetic description of it is still lacking. Here, we derived a set of reaction-diffusion equations for multiple RNA-induced silencing complex (RISC) pathways that give quantitative temporal and spatial descriptions of the siRNA process in mammalian cell, and are able to correctly describe all salient experimentally observed patterns of sub-cellular siRNA localization, including those that, at first glance, appear irreconcilable. These results suggest siRNA sub-cellular localization mainly concerns the non-catalytic RISC-target complex, and is caused by the selectiveness of RISC-target interaction and the permeability of the nuclear membrane to siRNA strands but not to RISC-target complexes. Our method is expected to be useful in devising RNAi based cell regulation strategies. Twit Text FOAVip Non-Catalytic RISCs and Kinetics Determine Mammalian siRNA Sub-Cellular Localization ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26699128 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26699128 #FOAvip English Wikipedia <ref>{{Cite pmid|26699128}}</ref> Non-Catalytic RISCs and Kinetics Determine Mammalian siRNA Sub-Cellular Localization #MMPMID26699128 Ji F; Liu L; Tien YH; Peng YH; Lee HC PLoS One 2015[]; 10 (12): ä PMID26699128show ga Small interfering RNAs (siRNAs) are fundamental to the regulation of cell function. Much is known about its gene interfering mechanism, but a kinetic description of it is still lacking. Here, we derived a set of reaction-diffusion equations for multiple RNA-induced silencing complex (RISC) pathways that give quantitative temporal and spatial descriptions of the siRNA process in mammalian cell, and are able to correctly describe all salient experimentally observed patterns of sub-cellular siRNA localization, including those that, at first glance, appear irreconcilable. These results suggest siRNA sub-cellular localization mainly concerns the non-catalytic RISC-target complex, and is caused by the selectiveness of RISC-target interaction and the permeability of the nuclear membrane to siRNA strands but not to RISC-target complexes. Our method is expected to be useful in devising RNAi based cell regulation strategies. äNon-Catalytic RISCs and Kinetics Determine Mammalian siRNA Sub-Cellula(epmc).pdf DeepDyve Pubget Overpricing