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10.1016/j.drudis.2014.06.014 http://scihub22266oqcxt.onion/10.1016/j.drudis.2014.06.014 C4689294!4689294!24955837     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Drug+Discov+Today 2014 ; 19 (8): 1270-6 Nephropedia Template TP {{tp|p=24955837|t=2014. Targeting the Wnt signaling pathways in pulmonary arterial hypertension |pdf=|usr=}}{{24955837}} gab.com Text Targeting the Wnt signaling pathways in pulmonary arterial hypertension JO: Drug Discov Today http://www.kidney.de/pget.php?&tw=1&pmid=24955837 #FOAvip Pulmonary arterial hypertension (PAH) is a life-threatening disorder that is associated with elevated pulmonary pressures and right heart failure resulting from progressive loss and thickening of small pulmonary arteries. Despite their ability to improve symptoms, current therapies fail to prevent disease progression, leaving lung transplantation as the only therapy in end-stage PAH. To overcome the limitations of current therapies, there is an active search for disease-modifying agents capable of altering the natural history of, and improving clinical outcomes in, PAH. The Wnt signaling pathways have emerged as attractive treatment targets in PAH given their role in the preservation of pulmonary vascular homeostasis and the recent development of Wnt-specific compounds and biological therapies capable of modulating pathway activity. In this review, we summarize the literature describing the role of Wnt signaling in the pulmonary circulation and discuss promising advances in the field of Wnt therapeutics that could lead to novel clinical therapies capable of preventing and/or reversing pulmonary vascular pathology in patients with this devastating disease. Twit Text FOAVip Targeting the Wnt signaling pathways in pulmonary arterial hypertension ????Drug Discov Today http://www.kidney.de/pget.php?&tw=1&pmid=24955837 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24955837 #FOAvip English Wikipedia <ref>{{Cite pmid|24955837}}</ref> Targeting the Wnt signaling pathways in pulmonary arterial hypertension #MMPMID24955837 de Jesus Perez V; Yuan K; Alastalo TP; Spiekerkoetter E; Rabinovitch M Drug Discov Today 2014[Aug]; 19 (8): 1270-6 PMID24955837show ga Pulmonary arterial hypertension (PAH) is a life-threatening disorder that is associated with elevated pulmonary pressures and right heart failure resulting from progressive loss and thickening of small pulmonary arteries. Despite their ability to improve symptoms, current therapies fail to prevent disease progression, leaving lung transplantation as the only therapy in end-stage PAH. To overcome the limitations of current therapies, there is an active search for disease-modifying agents capable of altering the natural history of, and improving clinical outcomes in, PAH. The Wnt signaling pathways have emerged as attractive treatment targets in PAH given their role in the preservation of pulmonary vascular homeostasis and the recent development of Wnt-specific compounds and biological therapies capable of modulating pathway activity. In this review, we summarize the literature describing the role of Wnt signaling in the pulmonary circulation and discuss promising advances in the field of Wnt therapeutics that could lead to novel clinical therapies capable of preventing and/or reversing pulmonary vascular pathology in patients with this devastating disease. äTargeting the Wnt signaling pathways in pulmonary arterial hypertensio(epmc).pdf DeepDyve Pubget Overpricing