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10.1158/1078-0432.CCR-14-0990 http://scihub22266oqcxt.onion/10.1158/1078-0432.CCR-14-0990 C4688961!4688961!25421725     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Cancer+Res 2015 ; 21 (2): 249-57 Nephropedia Template TP {{tp|p=25421725|t=2015. Imaging Intratumor Heterogeneity: Role in Therapy Response, Resistance, and Clinical Outcome |pdf=|usr=}}{{25421725}} gab.com Text Imaging Intratumor Heterogeneity: Role in Therapy Response, Resistance, and Clinical Outcome JO: Clin Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=25421725 #FOAvip Tumors exhibit genomic and phenotypic heterogeneity which has prognostic significance and may influence response to therapy. Imaging can quantify the spatial variation in architecture and function of individual tumors through quantifying basic biophysical parameters such as density or MRI signal relaxation rate; through measurements of blood flow, hypoxia, metabolism, cell death and other phenotypic features; and through mapping the spatial distribution of biochemical pathways and cell signaling networks. These methods can establish whether one tumor is more or less heterogeneous than another and can identify sub-regions with differing biology. In this article we review the image analysis methods currently used to quantify spatial heterogeneity within tumors. We discuss how analysis of intratumor heterogeneity can provide benefit over more simple biomarkers such as tumor size and average function. We consider how imaging methods can be integrated with genomic and pathology data, rather than be developed in isolation. Finally, we identify the challenges that must be overcome before measurements of intratumoral heterogeneity can be used routinely to guide patient care. Twit Text FOAVip Imaging Intratumor Heterogeneity: Role in Therapy Response, Resistance, and Clinical Outcome ????Clin Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=25421725 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25421725 #FOAvip English Wikipedia <ref>{{Cite pmid|25421725}}</ref> Imaging Intratumor Heterogeneity: Role in Therapy Response, Resistance, and Clinical Outcome #MMPMID25421725 O?Connor JP; Rose CJ; Waterton JC; Carano RA; Parker GJ; Jackson A Clin Cancer Res 2015[Jan]; 21 (2): 249-57 PMID25421725show ga Tumors exhibit genomic and phenotypic heterogeneity which has prognostic significance and may influence response to therapy. Imaging can quantify the spatial variation in architecture and function of individual tumors through quantifying basic biophysical parameters such as density or MRI signal relaxation rate; through measurements of blood flow, hypoxia, metabolism, cell death and other phenotypic features; and through mapping the spatial distribution of biochemical pathways and cell signaling networks. These methods can establish whether one tumor is more or less heterogeneous than another and can identify sub-regions with differing biology. In this article we review the image analysis methods currently used to quantify spatial heterogeneity within tumors. We discuss how analysis of intratumor heterogeneity can provide benefit over more simple biomarkers such as tumor size and average function. We consider how imaging methods can be integrated with genomic and pathology data, rather than be developed in isolation. Finally, we identify the challenges that must be overcome before measurements of intratumoral heterogeneity can be used routinely to guide patient care. äImaging Intratumor Heterogeneity: Role in Therapy Response, Resistance(epmc).pdf DeepDyve Pubget Overpricing