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10.1186/s40064-015-1598-y http://scihub22266oqcxt.onion/10.1186/s40064-015-1598-y C4688290!4688290 !26702389     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26702389 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Springerplus 2015 ; 4 (ä): 800 Nephropedia Template TP {{tp|p=26702389 |t=2015. The role of spleen in the treatment of experimental lipopolysaccharide-induced sepsis with dexmedetomidine |pdf=|usr=}}{{26702389 }} gab.com Text The role of spleen in the treatment of experimental lipopolysaccharide-induced sepsis with dexmedetomidine JO: Springerplus http://www.kidney.de/pget.php?&tw=1&pmid=26702389 #FOAvip Dexmedetomidine (Dex), a highly selective ?2-adrenergic receptor agonist, has been shown to attenuate systemic inflammatory response induced by lipopolysaccharide (LPS). The protective effects of Dex may reportedly be due to the activation of the ?7 nicotinic acetylcholine receptor (?7nAChR)-dependent cholinergic anti-inflammatory pathway. Spleen has been shown to play a pivotal role in the neural cholinergic anti-inflammatory pathway. However, little is known about the specific function of spleen in the protective effects of Dex against sepsis. To investigate the role of spleen in the treatment of Dex against sepsis, we studied the effects of preemptive administration of Dex to septic mice on the NF-?B p65 activation and downstream pro-inflammatory cytokine expression in the spleen. Our results provided evidence that Dex treatment attenuated LPS-activated NF-?B p65 activation, as well as the production of tumor necrosis factor-?, interleukin-6, and interleukin-1? at the level of both mRNA and protein in spleen. Consequently, serum concentrations of these cytokines decreased. Conversely, preemptive injection of ?-bungarotoxin, a selective ?7nAChR antagonist, reversed these effects of Dex. Our findings indicated that spleen played a critical role in the protective effects of Dex against sepsis and provided further insight into the anti-inflammatory mechanisms of Dex. Twit Text FOAVip The role of spleen in the treatment of experimental lipopolysaccharide-induced sepsis with dexmedetomidine ????Springerplus http://www.kidney.de/pget.php?&tw=1&pmid=26702389 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26702389 #FOAvip English Wikipedia <ref>{{Cite pmid|26702389 }}</ref> The role of spleen in the treatment of experimental lipopolysaccharide-induced sepsis with dexmedetomidine #MMPMID26702389 Liu Z ; Wang Y ; Ning Q ; Gong C ; Zhang Y ; Zhang L ; Bu X ; Jing G Springerplus 2015[]; 4 (ä): 800 PMID26702389 show ga Dexmedetomidine (Dex), a highly selective ?2-adrenergic receptor agonist, has been shown to attenuate systemic inflammatory response induced by lipopolysaccharide (LPS). The protective effects of Dex may reportedly be due to the activation of the ?7 nicotinic acetylcholine receptor (?7nAChR)-dependent cholinergic anti-inflammatory pathway. Spleen has been shown to play a pivotal role in the neural cholinergic anti-inflammatory pathway. However, little is known about the specific function of spleen in the protective effects of Dex against sepsis. To investigate the role of spleen in the treatment of Dex against sepsis, we studied the effects of preemptive administration of Dex to septic mice on the NF-?B p65 activation and downstream pro-inflammatory cytokine expression in the spleen. Our results provided evidence that Dex treatment attenuated LPS-activated NF-?B p65 activation, as well as the production of tumor necrosis factor-?, interleukin-6, and interleukin-1? at the level of both mRNA and protein in spleen. Consequently, serum concentrations of these cytokines decreased. Conversely, preemptive injection of ?-bungarotoxin, a selective ?7nAChR antagonist, reversed these effects of Dex. Our findings indicated that spleen played a critical role in the protective effects of Dex against sepsis and provided further insight into the anti-inflammatory mechanisms of Dex. äThe role of spleen in the treatment of experimental lipopolysaccharide(epmc).pdf DeepDyve Pubget Overpricing