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10.4161/23723548.2014.968507

http://scihub22266oqcxt.onion/10.4161/23723548.2014.968507
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C4687902!4687902!26709386
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suck abstract from ncbi


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pmid26709386      Mol+Cell+Oncol 2014 ; 1 (4): ä
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  • TAK1-dependent autophagy: A suppressor of fatty liver disease and hepatic oncogenesis #MMPMID26709386
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  • Mol Cell Oncol 2014[Oct]; 1 (4): ä PMID26709386show ga
  • In addition to regulating the activation of nuclear factor (NF)-?B and c-Jun N-terminal kinase (JNK), TGF-? activated kinase 1 (TAK1) also upregulates the activation of AMP-activated protein kinase (AMPK) and autophagy. In the liver, TAK1-mediated autophagy plays a role in preventing excessive lipid accumulation induced by starvation and fat overload. TAK1-mediated autophagy and inhibition of mechanistic target of rapamycin complex 1 (mTORC1) prevent liver fibrosis and tumor development.
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