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10.1158/2159-8290.CD-15-0671

http://scihub22266oqcxt.onion/10.1158/2159-8290.CD-15-0671
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C4687899!4687899!26534901
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suck abstract from ncbi


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pmid26534901      Cancer+Discov 2015 ; 5 (12): 1247-61
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  • Pancreatic Cancer Metabolism - Breaking it down to build it back up #MMPMID26534901
  • Perera RM; Bardeesy N
  • Cancer Discov 2015[Dec]; 5 (12): 1247-61 PMID26534901show ga
  • How do cancer cells escape tightly controlled regulatory circuits that link their proliferation to extracellular nutrient cues? An emerging theme in cancer biology is the hijacking of normal stress response mechanisms to enable growth even when nutrients are limiting. Pancreatic ductal adenocarcinoma (PDA) is the quintessential aggressive malignancy that thrives in nutrient-poor, hypoxic environments. PDAs overcome these limitations through appropriation of unorthodox strategies for fuel source acquisition and utilization. Additionally, interplay between evolving PDA and whole body metabolism contributes to disease pathogenesis. Deciphering how these pathways function and integrate with one another can reveal novel angles of therapeutic attack.
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