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10.1073/pnas.1512832112 http://scihub22266oqcxt.onion/10.1073/pnas.1512832112 C4687570!4687570!26607445     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (50): 15408-13 Nephropedia Template TP {{tp|p=26607445|t=2015. STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity |pdf=|usr=}}{{26607445}} gab.com Text STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26607445 #FOAvip Tumor recognition by the immune system can occur spontaneously but has usually little impact on tumor growth. However, the cellular and molecular mechanisms that drive these responses could be exploited therapeutically to generate efficacious antitumor immunity. Here, we show that stimulator of IFN genes (STING), a molecule involved in cytosolic DNA sensing and required for the generation of spontaneous antitumor immune responses, can be targeted by intratumoral injection of cGAMP to boost antitumor immunity and to control tumor growth. The immune response induced by therapeutic but also spontaneous STING activation was dependent on type I IFN produced by endothelial cells in the tumor microenvironment, unraveling an unexpected role of the tumor vasculature in the initiation of spontaneous and therapeutic antitumor immunity via STING. Twit Text FOAVip STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26607445 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26607445 #FOAvip English Wikipedia <ref>{{Cite pmid|26607445}}</ref> STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity #MMPMID26607445 Demaria O; De Gassart A; Coso S; Gestermann N; Di Domizio J; Flatz L; Gaide O; Michielin O; Hwu P; Petrova TV; Martinon F; Modlin RL; Speiser DE; Gilliet M Proc Natl Acad Sci U S A 2015[Dec]; 112 (50): 15408-13 PMID26607445show ga Tumor recognition by the immune system can occur spontaneously but has usually little impact on tumor growth. However, the cellular and molecular mechanisms that drive these responses could be exploited therapeutically to generate efficacious antitumor immunity. Here, we show that stimulator of IFN genes (STING), a molecule involved in cytosolic DNA sensing and required for the generation of spontaneous antitumor immune responses, can be targeted by intratumoral injection of cGAMP to boost antitumor immunity and to control tumor growth. The immune response induced by therapeutic but also spontaneous STING activation was dependent on type I IFN produced by endothelial cells in the tumor microenvironment, unraveling an unexpected role of the tumor vasculature in the initiation of spontaneous and therapeutic antitumor immunity via STING. äSTING activation of tumor endothelial cells initiates spontaneous and (epmc).pdf DeepDyve Pubget Overpricing