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Mitochondrial function in the brain links anxiety with social subordination #MMPMID26621716
Hollis F; van der Kooij MA; Zanoletti O; Lozano L; Cantó C; Sandi C
Proc Natl Acad Sci U S A 2015[Dec]; 112 (50): 15486-91 PMID26621716show ga
Within a dominance hierarchy, low social status strongly reduces individual well-being. In socially living species, rank in a hierarchy is determined through competitive encounters. Despite the numerous health consequences, the ability of personality traits to predispose individuals to a particular social rank remains largely unclear. Our work identifies trait anxiety as a predisposing factor to a subordinate rank. We demonstrate that mitochondrial function in the nucleus accumbens, a brain region relevant for motivation and depression, is a critical mediating factor in the subordinate status displayed by high-anxious rats. These findings highlight a role for cerebral energy metabolism in social behavior and point to mitochondrial function in the nucleus accumbens as a potential marker and avenue of treatment for mood disorders.