Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1126/science.aaa5414 http://scihub22266oqcxt.onion/10.1126/science.aaa5414 C4687482!4687482!25766227     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2015 ; 347 (6227): 1221-6 Nephropedia Template TP {{tp|p=25766227|t=2015. Synthesis of many different types of organic small molecules using one automated process |pdf=|usr=}}{{25766227}} gab.com Text Synthesis of many different types of organic small molecules using one automated process JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=25766227 #FOAvip Small molecule synthesis usually relies on procedures highly customized for each target. A broadly applicable automated process could greatly increase the accessibility of this class of compounds to enable investigations of their practical potential. Here we report the synthesis of 14 distinct classes of small molecules using the same fully automated process. This was achieved by strategically expanding the scope of a building block-based synthesis platform to include even Csp3-rich polycyclic natural product frameworks and discovering a catch-and-release chromatographic purification protocol applicable to all of the corresponding intermediates. With thousands of compatible building blocks already commercially available, many small molecules are now accessible with this platform. More broadly, these findings illuminate an actionable roadmap to a more general and automated approach for small molecule synthesis. Twit Text FOAVip Synthesis of many different types of organic small molecules using one automated process ????Science http://www.kidney.de/pget.php?&tw=1&pmid=25766227 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25766227 #FOAvip English Wikipedia <ref>{{Cite pmid|25766227}}</ref> Synthesis of many different types of organic small molecules using one automated process #MMPMID25766227 Li J; Ballmer SG; Gillis EP; Fujii S; Schmidt MJ; Palazzolo AME; Lehmann JW; Morehouse GF; Burke MD Science 2015[Mar]; 347 (6227): 1221-6 PMID25766227show ga Small molecule synthesis usually relies on procedures highly customized for each target. A broadly applicable automated process could greatly increase the accessibility of this class of compounds to enable investigations of their practical potential. Here we report the synthesis of 14 distinct classes of small molecules using the same fully automated process. This was achieved by strategically expanding the scope of a building block-based synthesis platform to include even Csp3-rich polycyclic natural product frameworks and discovering a catch-and-release chromatographic purification protocol applicable to all of the corresponding intermediates. With thousands of compatible building blocks already commercially available, many small molecules are now accessible with this platform. More broadly, these findings illuminate an actionable roadmap to a more general and automated approach for small molecule synthesis. äSynthesis of many different types of organic small molecules using one(epmc).pdf DeepDyve Pubget Overpricing