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10.15252/embr.201540717 http://scihub22266oqcxt.onion/10.15252/embr.201540717 C4687422!4687422!26538417     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+Rep 2015 ; 16 (12): 1723-36 Nephropedia Template TP {{tp|p=26538417|t=2015. Myc coordinates transcription and translation to enhance transformation and suppress invasiveness |pdf=|usr=}}{{26538417}} gab.com Text Myc coordinates transcription and translation to enhance transformation and suppress invasiveness JO: EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=26538417 #FOAvip c?Myc is one of the major human proto?oncogenes and is often associated with tumor aggression and poor clinical outcome. Paradoxically, Myc was also reported as a suppressor of cell motility, invasiveness, and metastasis. Among the direct targets of Myc are many components of the protein synthesis machinery whose induction results in an overall increase in protein synthesis that empowers tumor cell growth. At present, it is largely unknown whether beyond the global enhancement of protein synthesis, Myc activation results in translation modulation of specific genes. Here, we measured Myc?induced global changes in gene expression at the transcription, translation, and protein levels and uncovered extensive transcript?specific regulation of protein translation. Particularly, we detected a broad coordination between regulation of transcription and translation upon modulation of Myc activity and showed the connection of these responses to mTOR signaling to enhance oncogenic transformation and to the TGF? pathway to modulate cell migration and invasiveness. Our results elucidate novel facets of Myc?induced cellular responses and provide a more comprehensive view of the consequences of its activation in cancer cells. Twit Text FOAVip Myc coordinates transcription and translation to enhance transformation and suppress invasiveness ????EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=26538417 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26538417 #FOAvip English Wikipedia <ref>{{Cite pmid|26538417}}</ref> Myc coordinates transcription and translation to enhance transformation and suppress invasiveness #MMPMID26538417 Elkon R; Loayza?Puch F; Korkmaz G; Lopes R; van Breugel PC; Bleijerveld OB; Altelaar AM; Wolf E; Lorenzin F; Eilers M; Agami R EMBO Rep 2015[Dec]; 16 (12): 1723-36 PMID26538417show ga c?Myc is one of the major human proto?oncogenes and is often associated with tumor aggression and poor clinical outcome. Paradoxically, Myc was also reported as a suppressor of cell motility, invasiveness, and metastasis. Among the direct targets of Myc are many components of the protein synthesis machinery whose induction results in an overall increase in protein synthesis that empowers tumor cell growth. At present, it is largely unknown whether beyond the global enhancement of protein synthesis, Myc activation results in translation modulation of specific genes. Here, we measured Myc?induced global changes in gene expression at the transcription, translation, and protein levels and uncovered extensive transcript?specific regulation of protein translation. Particularly, we detected a broad coordination between regulation of transcription and translation upon modulation of Myc activity and showed the connection of these responses to mTOR signaling to enhance oncogenic transformation and to the TGF? pathway to modulate cell migration and invasiveness. Our results elucidate novel facets of Myc?induced cellular responses and provide a more comprehensive view of the consequences of its activation in cancer cells. äMyc coordinates transcription and translation to enhance transformatio(epmc).pdf DeepDyve Pubget Overpricing