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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 BioData+Min 2015 ; 8 (ä): ä Nephropedia Template TP
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Non-coding yet non-trivial: a review on the computational genomics of lincRNAs #MMPMID26697116
Ching T; Masaki J; Weirather J; Garmire LX
BioData Min 2015[]; 8 (ä): ä PMID26697116show ga
Long intergenic non-coding RNAs (lincRNAs) represent one of the most mysterious RNA species encoded by the human genome. Thanks to next generation sequencing (NGS) technology and its applications, we have recently witnessed a surge in non-coding RNA research, including lincRNA research. Here, we summarize the recent advancement in genomics studies of lincRNAs. We review the emerging characteristics of lincRNAs, the experimental and computational approaches to identify lincRNAs, their known mechanisms of regulation, the computational methods and resources for lincRNA functional predictions, and discuss the challenges to understanding lincRNA comprehensively.