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10.1186/s13024-015-0065-0 http://scihub22266oqcxt.onion/10.1186/s13024-015-0065-0 C4687091!4687091 !26692002     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26692002 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Neurodegener 2015 ; 10 (ä): 69 Nephropedia Template TP {{tp|p=26692002 |t=2015. Beclin 1 regulates neuronal transforming growth factor-? signaling by mediating recycling of the type I receptor ALK5 |pdf=|usr=}}{{26692002 }} gab.com Text Beclin 1 regulates neuronal transforming growth factor- signaling by mediating recycling of the type I receptor ALK5 JO: Mol Neurodegener http://www.kidney.de/pget.php?&tw=1&pmid=26692002 #FOAvip BACKGROUND: Beclin 1 is a key regulator of multiple trafficking pathways, including autophagy and receptor recycling in yeast and microglia. Decreased beclin 1 levels in the CNS result in neurodegeneration, an effect attributed to impaired autophagy. However, neurons also rely heavily on trophic factors, and signaling through these pathways requires the proper trafficking of trophic factor receptors. RESULTS: We discovered that beclin 1 regulates signaling through the neuroprotective TGF-? pathway. Beclin 1 is required for recycling of the type I TGF-? receptor ALK5. We show that beclin 1 recruits the retromer to ALK5 and facilitates its localization to Rab11(+) endosomes. Decreased levels of beclin 1, or its binding partners VPS34 and UVRAG, impair TGF-? signaling. CONCLUSIONS: These findings identify beclin 1 as a positive regulator of a trophic signaling pathway via receptor recycling, and suggest that neuronal death induced by decreased beclin 1 levels may also be due to impaired trophic factor signaling. Twit Text FOAVip Beclin 1 regulates neuronal transforming growth factor- signaling by mediating recycling of the type I receptor ALK5 ????Mol Neurodegener http://www.kidney.de/pget.php?&tw=1&pmid=26692002 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26692002 #FOAvip English Wikipedia <ref>{{Cite pmid|26692002 }}</ref> Beclin 1 regulates neuronal transforming growth factor-? signaling by mediating recycling of the type I receptor ALK5 #MMPMID26692002 O'Brien CE ; Bonanno L ; Zhang H ; Wyss-Coray T Mol Neurodegener 2015[Dec]; 10 (ä): 69 PMID26692002 show ga BACKGROUND: Beclin 1 is a key regulator of multiple trafficking pathways, including autophagy and receptor recycling in yeast and microglia. Decreased beclin 1 levels in the CNS result in neurodegeneration, an effect attributed to impaired autophagy. However, neurons also rely heavily on trophic factors, and signaling through these pathways requires the proper trafficking of trophic factor receptors. RESULTS: We discovered that beclin 1 regulates signaling through the neuroprotective TGF-? pathway. Beclin 1 is required for recycling of the type I TGF-? receptor ALK5. We show that beclin 1 recruits the retromer to ALK5 and facilitates its localization to Rab11(+) endosomes. Decreased levels of beclin 1, or its binding partners VPS34 and UVRAG, impair TGF-? signaling. CONCLUSIONS: These findings identify beclin 1 as a positive regulator of a trophic signaling pathway via receptor recycling, and suggest that neuronal death induced by decreased beclin 1 levels may also be due to impaired trophic factor signaling. |Animals [MESH] |Apoptosis Regulatory Proteins/*metabolism [MESH] |Autophagy/physiology [MESH] |Beclin-1 [MESH] |Endosomes/metabolism [MESH] |Mice [MESH] |Microglia/*metabolism [MESH] |Protein Serine-Threonine Kinases/*metabolism [MESH] |Protein Transport/physiology [MESH] |Receptor, Transforming Growth Factor-beta Type I [MESH] |Receptors, Transforming Growth Factor beta/*metabolism [MESH] |Signal Transduction/*physiology [MESH]Beclin 1 regulates neuronal transforming growth factor-? signaling by (epmc).pdf DeepDyve Pubget Overpricing