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10.1038/nrendo.2014.226 http://scihub22266oqcxt.onion/10.1038/nrendo.2014.226 C4687015!4687015!25560705     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Rev+Endocrinol 2015 ; 11 (3): 171-81 Nephropedia Template TP {{tp|p=25560705|t=2015. Recognizing the Putative Role for TSH Receptor Expressing Fibrocytes in Thyroid-Associated Ophthalmopathy may solve several mysteries |pdf=|usr=}}{{25560705}} gab.com Text Recognizing the Putative Role for TSH Receptor Expressing Fibrocytes in Thyroid-Associated Ophthalmopathy may solve several mysteries JO: Nat Rev Endocrinol http://www.kidney.de/pget.php?&tw=1&pmid=25560705 #FOAvip Thyroid-associated ophthalmopathy (TAO) remains the vexing and undertreated ocular component of Graves? disease where orbital tissues undergo extensive remodeling. We have recently introduced the concept that CD34+ fibrocytes, bone marrow derived monocyte lineage precursor cells express the thyrotropin receptor (TSHR) and several other proteins traditionally thought to be expressed uniquely in the thyroid. TSHR-engaged fibrocytes generate extremely high levels of several inflammatory cytokines. Acting in concert with TSHR, the insulin-like growth factor 1 receptor (IGF-1R) expressed by fibrocytes appears to be necessary for TSHR-dependent cytokine production since anti-IGF-1R blocking antibodies attenuate these actions of TSH. Further, circulating fibrocytes become more abundant and appear to infiltrate orbital connective tissues in TAO where they may transition to CD34+ fibroblasts. We currently postulate that the infiltration of fibrocytes into the orbit and their unique biosynthetic repertoire and proinflammatory/profibrotic phenotype account for the characteristic properties exhibited by orbital connective tissues that render them susceptible to TAO. Further, it may be possible to utilize these very recent insights to therapeutically target pathogenic orbital fibrocytes selectively utilizing recently developed biologic agents which interfere with TSHR and IGF-1R signaling. Twit Text FOAVip Recognizing the Putative Role for TSH Receptor Expressing Fibrocytes in Thyroid-Associated Ophthalmopathy may solve several mysteries ????Nat Rev Endocrinol http://www.kidney.de/pget.php?&tw=1&pmid=25560705 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25560705 #FOAvip English Wikipedia <ref>{{Cite pmid|25560705}}</ref> Recognizing the Putative Role for TSH Receptor Expressing Fibrocytes in Thyroid-Associated Ophthalmopathy may solve several mysteries #MMPMID25560705 Smith TJ Nat Rev Endocrinol 2015[Mar]; 11 (3): 171-81 PMID25560705show ga Thyroid-associated ophthalmopathy (TAO) remains the vexing and undertreated ocular component of Graves? disease where orbital tissues undergo extensive remodeling. We have recently introduced the concept that CD34+ fibrocytes, bone marrow derived monocyte lineage precursor cells express the thyrotropin receptor (TSHR) and several other proteins traditionally thought to be expressed uniquely in the thyroid. TSHR-engaged fibrocytes generate extremely high levels of several inflammatory cytokines. Acting in concert with TSHR, the insulin-like growth factor 1 receptor (IGF-1R) expressed by fibrocytes appears to be necessary for TSHR-dependent cytokine production since anti-IGF-1R blocking antibodies attenuate these actions of TSH. Further, circulating fibrocytes become more abundant and appear to infiltrate orbital connective tissues in TAO where they may transition to CD34+ fibroblasts. We currently postulate that the infiltration of fibrocytes into the orbit and their unique biosynthetic repertoire and proinflammatory/profibrotic phenotype account for the characteristic properties exhibited by orbital connective tissues that render them susceptible to TAO. Further, it may be possible to utilize these very recent insights to therapeutically target pathogenic orbital fibrocytes selectively utilizing recently developed biologic agents which interfere with TSHR and IGF-1R signaling. äRecognizing the Putative Role for TSH Receptor Expressing Fibrocytes i(epmc).pdf DeepDyve Pubget Overpricing