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10.1038/emm.2015.96 http://scihub22266oqcxt.onion/10.1038/emm.2015.96 C4686698/?report=reader!4686698!27534531     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Exp+Mol+Med 2016 ; 48 (1): e202- Nephropedia Template TP {{tp|p=27534531|t=2016. Aspirin induces IL-4 production: augmented IL-4 production in aspirin-exacerbated respiratory disease |pdf=|usr=}}{{27534531}} gab.com Text Aspirin induces IL-4 production: augmented IL-4 production in aspirin-exacerbated respiratory disease JO: Exp Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=27534531 #FOAvip Aspirin hypersensitivity is a hallmark of aspirin-exacerbated respiratory disease (AERD), a clinical syndrome characterized by the severe inflammation of the respiratory tract after ingestion of cyclooxygenase-1 inhibitors. We investigated the capacity of aspirin to induce interleukin-4 (IL-4) production in inflammatory cells relevant to AERD pathogenesis and examined the associated biochemical and molecular pathways. We also compared IL-4 production in peripheral blood mononuclear cells (PBMCs) from patients with AERD vs aspirin-tolerant asthma (ATA) upon exposure to aspirin. Aspirin induced IL-4 expression and activated the IL-4 promoter in a report assay. The capacity of aspirin to induce IL-4 expression correlated with its activity to activate mitogen-activated protein kinases, to form DNA?protein complexes on P elements in the IL-4 promoter and to synthesize nuclear factor of activated T cells, critical transcription factors for IL-4 transcription. Of clinical importance, aspirin upregulated IL-4 production twice as much in PBMCs from patients with AERD compared with PBMCs from patients with ATA. Our results suggest that IL-4 is an inflammatory component mediating intolerance reactions to aspirin, and thus is crucial for AERD pathogenesis. Twit Text FOAVip Aspirin induces IL-4 production: augmented IL-4 production in aspirin-exacerbated respiratory disease ????Exp Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=27534531 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27534531 #FOAvip English Wikipedia <ref>{{Cite pmid|27534531}}</ref> Aspirin induces IL-4 production: augmented IL-4 production in aspirin-exacerbated respiratory disease #MMPMID27534531 Kong SK; Soo Kim B; Gi Uhm T; Soo Chang H; Sook Park J; Woo Park S; Park CS; Chung IY Exp Mol Med 2016[Jan]; 48 (1): e202- PMID27534531show ga Aspirin hypersensitivity is a hallmark of aspirin-exacerbated respiratory disease (AERD), a clinical syndrome characterized by the severe inflammation of the respiratory tract after ingestion of cyclooxygenase-1 inhibitors. We investigated the capacity of aspirin to induce interleukin-4 (IL-4) production in inflammatory cells relevant to AERD pathogenesis and examined the associated biochemical and molecular pathways. We also compared IL-4 production in peripheral blood mononuclear cells (PBMCs) from patients with AERD vs aspirin-tolerant asthma (ATA) upon exposure to aspirin. Aspirin induced IL-4 expression and activated the IL-4 promoter in a report assay. The capacity of aspirin to induce IL-4 expression correlated with its activity to activate mitogen-activated protein kinases, to form DNA?protein complexes on P elements in the IL-4 promoter and to synthesize nuclear factor of activated T cells, critical transcription factors for IL-4 transcription. Of clinical importance, aspirin upregulated IL-4 production twice as much in PBMCs from patients with AERD compared with PBMCs from patients with ATA. Our results suggest that IL-4 is an inflammatory component mediating intolerance reactions to aspirin, and thus is crucial for AERD pathogenesis. äAspirin induces IL-4 production: augmented IL-4 production in aspirin-(epmc).pdf DeepDyve Pubget Overpricing