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10.1038/emm.2015.91 http://scihub22266oqcxt.onion/10.1038/emm.2015.91 C4686695!4686695!26655831     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Exp+Mol+Med 2015 ; 47 (12): e198- Nephropedia Template TP {{tp|p=26655831|t=2015. The Wnt/?-catenin signaling pathway regulates the development of airway remodeling in patients with asthma |pdf=|usr=}}{{26655831}} gab.com Text The Wnt/ -catenin signaling pathway regulates the development of airway remodeling in patients with asthma JO: Exp Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=26655831 #FOAvip Airway remodeling is a key characteristic of chronic asthma, particularly in patients with a fixed airflow limitation. The mechanisms underlying airway remodeling are poorly understood, and no therapeutic option is available. The Wnt/?-catenin signaling pathway is involved in various physiological and pathological processes, including fibrosis and smooth muscle hypertrophy. In this study, we investigated the roles of Wnt/?-catenin signaling in airway remodeling in patients with asthma. Wnt7a mRNA expression was prominent in induced sputum from patients with asthma compared with that from healthy controls. Next, we induced a chronic asthma mouse model with airway remodeling features, including subepithelial fibrosis and airway smooth muscle hyperplasia. Higher expression of Wnt family proteins and ?-catenin was detected in the lung tissue of mice with chronic asthma compared to control mice. Blocking ?-catenin expression with a specific siRNA attenuated airway inflammation and airway remodeling. Decreased subepithelial fibrosis and collagen accumulation in the ?-catenin siRNA-treated mice was accompanied by reduced expression of transforming growth factor-?. We further showed that suppressing ?-catenin in the chronic asthma model inhibited smooth muscle hyperplasia by downregulating the tenascin C/platelet-derived growth factor receptor pathway. Taken together, these findings demonstrate that the Wnt/?-catenin signaling pathway is highly expressed and regulates the development of airway remodeling in chronic asthma. Twit Text FOAVip The Wnt/ -catenin signaling pathway regulates the development of airway remodeling in patients with asthma ????Exp Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=26655831 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26655831 #FOAvip English Wikipedia <ref>{{Cite pmid|26655831}}</ref> The Wnt/?-catenin signaling pathway regulates the development of airway remodeling in patients with asthma #MMPMID26655831 Kwak HJ; Park DW; Seo JY; Moon JY; Kim TH; Sohn JW; Shin DH; Yoon HJ; Park SS; Kim SH Exp Mol Med 2015[Dec]; 47 (12): e198- PMID26655831show ga Airway remodeling is a key characteristic of chronic asthma, particularly in patients with a fixed airflow limitation. The mechanisms underlying airway remodeling are poorly understood, and no therapeutic option is available. The Wnt/?-catenin signaling pathway is involved in various physiological and pathological processes, including fibrosis and smooth muscle hypertrophy. In this study, we investigated the roles of Wnt/?-catenin signaling in airway remodeling in patients with asthma. Wnt7a mRNA expression was prominent in induced sputum from patients with asthma compared with that from healthy controls. Next, we induced a chronic asthma mouse model with airway remodeling features, including subepithelial fibrosis and airway smooth muscle hyperplasia. Higher expression of Wnt family proteins and ?-catenin was detected in the lung tissue of mice with chronic asthma compared to control mice. Blocking ?-catenin expression with a specific siRNA attenuated airway inflammation and airway remodeling. Decreased subepithelial fibrosis and collagen accumulation in the ?-catenin siRNA-treated mice was accompanied by reduced expression of transforming growth factor-?. We further showed that suppressing ?-catenin in the chronic asthma model inhibited smooth muscle hyperplasia by downregulating the tenascin C/platelet-derived growth factor receptor pathway. Taken together, these findings demonstrate that the Wnt/?-catenin signaling pathway is highly expressed and regulates the development of airway remodeling in chronic asthma. äThe Wnt/?-catenin signaling pathway regulates the development of airwa(epmc).pdf DeepDyve Pubget Overpricing