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10.1007/s13361-015-1253-4 http://scihub22266oqcxt.onion/10.1007/s13361-015-1253-4 C4686549!4686549 !26486514     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26486514 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Am+Soc+Mass+Spectrom 2016 ; 27 (1 ): 4-21 Nephropedia Template TP {{tp|p=26486514 |t=2016. "Magic" Ionization Mass Spectrometry |pdf=|usr=}}{{26486514 }} gab.com Text "Magic" Ionization Mass Spectrometry JO: J Am Soc Mass Spectrom http://www.kidney.de/pget.php?&tw=1&pmid=26486514 #FOAvip The systematic study of the temperature and pressure dependence of matrix-assisted ionization (MAI) led us to the discovery of the seemingly impossible, initially explained by some reviewers as either sleight of hand or the misinterpretation by an overzealous young scientist of results reported many years before and having little utility. The ?magic? that we were attempting to report was that with matrix assistance, molecules, at least as large as bovine serum albumin (66 kDa), are lifted into the gas phase as multiply charged ions simply by exposure of the matrix:analyte sample to the vacuum of a mass spectrometer. Applied heat, a laser, or voltages are not necessary to achieve charge states and ion abundances only previously observed with electrospray ionization (ESI). The fundamentals of how solid phase volatile or nonvolatile compounds are converted to gas-phase ions without added energy currently involves speculation providing a great opportunity to rethink mechanistic understanding of ionization processes used in mass spectrometry. Improved understanding of the mechanism(s) of these processes and their connection to ESI and matrix-assisted laser desorption/ionization may provide opportunities to further develop new ionization strategies for traditional and yet unforeseen applications of mass spectrometry. This Critical Insights article covers developments leading to the discovery of a seemingly magic ionization process that is simple to use, fast, sensitive, robust, and can be directly applied to surface characterization using portable or high performance mass spectrometers. Twit Text FOAVip "Magic" Ionization Mass Spectrometry ????J Am Soc Mass Spectrom http://www.kidney.de/pget.php?&tw=1&pmid=26486514 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26486514 #FOAvip English Wikipedia <ref>{{Cite pmid|26486514 }}</ref> "Magic" Ionization Mass Spectrometry #MMPMID26486514 Trimpin S J Am Soc Mass Spectrom 2016[Jan]; 27 (1 ): 4-21 PMID26486514 show ga The systematic study of the temperature and pressure dependence of matrix-assisted ionization (MAI) led us to the discovery of the seemingly impossible, initially explained by some reviewers as either sleight of hand or the misinterpretation by an overzealous young scientist of results reported many years before and having little utility. The ?magic? that we were attempting to report was that with matrix assistance, molecules, at least as large as bovine serum albumin (66 kDa), are lifted into the gas phase as multiply charged ions simply by exposure of the matrix:analyte sample to the vacuum of a mass spectrometer. Applied heat, a laser, or voltages are not necessary to achieve charge states and ion abundances only previously observed with electrospray ionization (ESI). The fundamentals of how solid phase volatile or nonvolatile compounds are converted to gas-phase ions without added energy currently involves speculation providing a great opportunity to rethink mechanistic understanding of ionization processes used in mass spectrometry. Improved understanding of the mechanism(s) of these processes and their connection to ESI and matrix-assisted laser desorption/ionization may provide opportunities to further develop new ionization strategies for traditional and yet unforeseen applications of mass spectrometry. This Critical Insights article covers developments leading to the discovery of a seemingly magic ionization process that is simple to use, fast, sensitive, robust, and can be directly applied to surface characterization using portable or high performance mass spectrometers. |*Spectrometry, Mass, Electrospray Ionization [MESH] |Gases/*chemistry [MESH] |Ions/analysis/chemistry [MESH] |Pressure [MESH] |Proteins [MESH]"Magic" Ionization Mass Spectrometry (epmc).pdf DeepDyve Pubget Overpricing