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10.3892/mmr.2015.4580 http://scihub22266oqcxt.onion/10.3892/mmr.2015.4580 C4686073!4686073 !26647757     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26647757 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Med+Rep 2016 ; 13 (1 ): 661-8 Nephropedia Template TP {{tp|p=26647757 |t=2016. Valproate attenuates diabetic nephropathy through inhibition of endoplasmic reticulum stress?induced apoptosis |pdf=|usr=}}{{26647757 }} gab.com Text Valproate attenuates diabetic nephropathy through inhibition of endoplasmic reticulum stress induced apoptosis JO: Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=26647757 #FOAvip Previous studies have suggested that endoplasmic reticulum stress (ERS) is one of the mechanisms responsible for the pathogenesis of diabetic nephropathy (DN). Histone acetylation modification can regulate the transcription of genes and is involved in the regulation of ERS. Valproate (VPA), a nonselective histone deacetylase inhibitor, has been reported to have a protective role in kidney tissue injury, however, whether VPA can prevent DN remains to be elucidated. In the present study, it was found that VPA increases the expression of glucose?regulated protein (GRP78) and reduces the protein expression of C/EBP?homologous protein (CHOP), growth arrest and DNA?damage?inducible gene 153 and caspase?12 in a rat model of DN. VPA can reduce renal cell apoptosis and alleviate proteinuria and alterations in serum creatinine. VPA also upregulates the acetylation level of histone H4 in the promoter of GRP78 and downregulates the acetylation level of histone H4 in the promoter of CHOP. Collectively, the data indicate that VPA can relieve ERS and reduce renal cell apoptosis, and thus attenuate renal injury in a rat model of DN by regulating the acetylation level of histone H4 in ERS?associated protein promoters. Twit Text FOAVip Valproate attenuates diabetic nephropathy through inhibition of endoplasmic reticulum stress induced apoptosis ????Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=26647757 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26647757 #FOAvip English Wikipedia <ref>{{Cite pmid|26647757 }}</ref> Valproate attenuates diabetic nephropathy through inhibition of endoplasmic reticulum stress?induced apoptosis #MMPMID26647757 Sun XY ; Qin HJ ; Zhang Z ; Xu Y ; Yang XC ; Zhao DM ; Li XN ; Sun LK Mol Med Rep 2016[Jan]; 13 (1 ): 661-8 PMID26647757 show ga Previous studies have suggested that endoplasmic reticulum stress (ERS) is one of the mechanisms responsible for the pathogenesis of diabetic nephropathy (DN). Histone acetylation modification can regulate the transcription of genes and is involved in the regulation of ERS. Valproate (VPA), a nonselective histone deacetylase inhibitor, has been reported to have a protective role in kidney tissue injury, however, whether VPA can prevent DN remains to be elucidated. In the present study, it was found that VPA increases the expression of glucose?regulated protein (GRP78) and reduces the protein expression of C/EBP?homologous protein (CHOP), growth arrest and DNA?damage?inducible gene 153 and caspase?12 in a rat model of DN. VPA can reduce renal cell apoptosis and alleviate proteinuria and alterations in serum creatinine. VPA also upregulates the acetylation level of histone H4 in the promoter of GRP78 and downregulates the acetylation level of histone H4 in the promoter of CHOP. Collectively, the data indicate that VPA can relieve ERS and reduce renal cell apoptosis, and thus attenuate renal injury in a rat model of DN by regulating the acetylation level of histone H4 in ERS?associated protein promoters. |Acetylation [MESH] |Animals [MESH] |Apoptosis/*drug effects [MESH] |Diabetic Nephropathies/*drug therapy/*pathology [MESH] |Disease Models, Animal [MESH] |Endoplasmic Reticulum Chaperone BiP [MESH] |Endoplasmic Reticulum Stress/*drug effects [MESH] |Heat-Shock Proteins/genetics [MESH] |Histones/metabolism [MESH] |Kidney/drug effects/injuries/pathology [MESH] |Male [MESH] |Mitochondria/drug effects/metabolism [MESH] |Promoter Regions, Genetic/genetics [MESH] |Rats, Wistar [MESH] |Transcription Factor CHOP/genetics/metabolism [MESH]Valproate attenuates diabetic nephropathy through inhibition of endopl(epmc).pdf DeepDyve Pubget Overpricing