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10.3892/mmr.2015.4568 http://scihub22266oqcxt.onion/10.3892/mmr.2015.4568 C4686059!4686059 !26572589     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26572589 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Med+Rep 2016 ; 13 (1 ): 75-82 Nephropedia Template TP {{tp|p=26572589 |t=2016. MicroRNA-21 stimulates epithelial-to-mesenchymal transition and tumorigenesis in clear cell renal cells |pdf=|usr=}}{{26572589 }} gab.com Text MicroRNA-21 stimulates epithelial-to-mesenchymal transition and tumorigenesis in clear cell renal cells JO: Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=26572589 #FOAvip Clear cell renal cell carcinoma (ccRCC) metastasis may result from epithelial-to-mesenchymal transition and mesenchymal stem cells that contribute to the development of the primary tumor. In this study, it was demonstrated that microRNA-21 (miR-21) acts as an oncogenic driver of ccRCC. ccRCC spheres were isolated and it was shown that they exhibited cancer stem cell?like properties, including the formation of self?renewing spheres. Spheres showed increased expression of stem cell?related transcription factors and epithelial?mesenchymal transition (EMT) markers. In addition, secondary sphere formation capacity was assessed after miR?21 transfection. miR?21 accelerated the formation of ccRCC spheres, which shared molecular characteristics with the spontaneous ccRCC spheres. It was demonstrated that miR?21 overexpression facilitates ccRCC sphere formation. Thus, a single miRNA may have an impact on the formation of highly tumorigenic cancer spheres in kidney cancer. Twit Text FOAVip MicroRNA-21 stimulates epithelial-to-mesenchymal transition and tumorigenesis in clear cell renal cells ????Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=26572589 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26572589 #FOAvip English Wikipedia <ref>{{Cite pmid|26572589 }}</ref> MicroRNA-21 stimulates epithelial-to-mesenchymal transition and tumorigenesis in clear cell renal cells #MMPMID26572589 Cao J ; Liu J ; Xu R ; Zhu X ; Liu L ; Zhao X Mol Med Rep 2016[Jan]; 13 (1 ): 75-82 PMID26572589 show ga Clear cell renal cell carcinoma (ccRCC) metastasis may result from epithelial-to-mesenchymal transition and mesenchymal stem cells that contribute to the development of the primary tumor. In this study, it was demonstrated that microRNA-21 (miR-21) acts as an oncogenic driver of ccRCC. ccRCC spheres were isolated and it was shown that they exhibited cancer stem cell?like properties, including the formation of self?renewing spheres. Spheres showed increased expression of stem cell?related transcription factors and epithelial?mesenchymal transition (EMT) markers. In addition, secondary sphere formation capacity was assessed after miR?21 transfection. miR?21 accelerated the formation of ccRCC spheres, which shared molecular characteristics with the spontaneous ccRCC spheres. It was demonstrated that miR?21 overexpression facilitates ccRCC sphere formation. Thus, a single miRNA may have an impact on the formation of highly tumorigenic cancer spheres in kidney cancer. |Apoptosis/genetics [MESH] |Carcinogenesis/*genetics/pathology [MESH] |Carcinoma, Renal Cell/*genetics/*pathology [MESH] |Cell Line, Tumor [MESH] |Cell Movement/genetics [MESH] |Cell Proliferation [MESH] |Cell Separation [MESH] |Epithelial-Mesenchymal Transition/*genetics [MESH] |Female [MESH] |Flow Cytometry [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Humans [MESH] |Kidney Neoplasms/*genetics/*pathology [MESH] |Male [MESH] |MicroRNAs/genetics/*metabolism [MESH] |Middle Aged [MESH] |Neoplasm Invasiveness [MESH] |Spheroids, Cellular/metabolism/pathology [MESH] |Up-Regulation/genetics [MESH]MicroRNA-21 stimulates epithelial-to-mesenchymal transition and tumori(epmc).pdf DeepDyve Pubget Overpricing