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10.1016/j.celrep.2015.11.010 http://scihub22266oqcxt.onion/10.1016/j.celrep.2015.11.010 C4684902!4684902!26673320     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2015 ; 13 (10): 2107-17 Nephropedia Template TP {{tp|p=26673320|t=2015. Direct in vivo manipulation and imaging of calcium transients in neutrophils identifies a critical role for leading-edge calcium flux |pdf=|usr=}}{{26673320}} gab.com Text Direct in vivo manipulation and imaging of calcium transients in neutrophils identifies a critical role for leading-edge calcium flux JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=26673320 #FOAvip Calcium signaling has long been associated with key events of immunity, including chemotaxis, phagocytosis, and activation. However, imaging and manipulation of calcium flux in motile immune cells in live animals remains challenging. Using light-sheet microscopy for in vivo calcium imaging in zebrafish, we observe characteristic patterns of calcium flux triggered by distinct events, including phagocytosis of pathogenic bacteria and migration of neutrophils toward inflammatory stimuli. In contrast to findings from ex vivo studies, we observe enriched calcium influx at the leading edge of migrating neutrophils. To directly manipulate calcium dynamics in vivo, we have developed transgenic lines with cell-specific expression of the mammalian TRPV1 channel, enabling ligand-gated, reversible and spatiotemporal control of calcium influx. We find that controlled calcium influx can function to help define the neutrophil?s leading edge. Cell-specific TRPV1 expression may have broad utility for precise control of calcium dynamics in other immune cell types and organisms. Twit Text FOAVip Direct in vivo manipulation and imaging of calcium transients in neutrophils identifies a critical role for leading-edge calcium flux ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=26673320 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26673320 #FOAvip English Wikipedia <ref>{{Cite pmid|26673320}}</ref> Direct in vivo manipulation and imaging of calcium transients in neutrophils identifies a critical role for leading-edge calcium flux #MMPMID26673320 Beerman RW; Matty MA; Au GG; Looger LL; Choudhury KR; Keller PJ; Tobin DM Cell Rep 2015[Dec]; 13 (10): 2107-17 PMID26673320show ga Calcium signaling has long been associated with key events of immunity, including chemotaxis, phagocytosis, and activation. However, imaging and manipulation of calcium flux in motile immune cells in live animals remains challenging. Using light-sheet microscopy for in vivo calcium imaging in zebrafish, we observe characteristic patterns of calcium flux triggered by distinct events, including phagocytosis of pathogenic bacteria and migration of neutrophils toward inflammatory stimuli. In contrast to findings from ex vivo studies, we observe enriched calcium influx at the leading edge of migrating neutrophils. To directly manipulate calcium dynamics in vivo, we have developed transgenic lines with cell-specific expression of the mammalian TRPV1 channel, enabling ligand-gated, reversible and spatiotemporal control of calcium influx. We find that controlled calcium influx can function to help define the neutrophil?s leading edge. Cell-specific TRPV1 expression may have broad utility for precise control of calcium dynamics in other immune cell types and organisms. äDirect in vivo manipulation and imaging of calcium transients in neutr(epmc).pdf DeepDyve Pubget Overpricing