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10.1016/j.ijsu.2015.07.724 http://scihub22266oqcxt.onion/10.1016/j.ijsu.2015.07.724 C4684721!4684721!26306769     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Surg 2015 ; 23 (0 0): 223-8 Nephropedia Template TP {{tp|p=26306769|t=2015. Recent Investigations into Pig Antigen and Anti-Pig Antibody Expression |pdf=|usr=}}{{26306769}} gab.com Text Recent Investigations into Pig Antigen and Anti-Pig Antibody Expression JO: Int J Surg http://www.kidney.de/pget.php?&tw=1&pmid=26306769 #FOAvip Genetic engineering of donor pigs to eliminate expression of the dominant xenogeneic antigen galactose ?1,3 galactose (Gal) has created a sea change in the immunobiology of xenograft rejection. Antibody mediated xenograft rejection of GGTA-1 ?-galactosyltransferase (GTKO) deficient organs is now directed to a combination of non-Gal pig protein and carbohydrate antigens. Glycan analysis of GTKO tissues identified no new neo-antigens but detected high levels of N-acetylneuraminic acid (Neu5Gc) modified glycoproteins and glycolipids. Humans produce anti-Neu5Gc antibody and in very limited clinical studies sometimes show an induced anti-Neu5Gc antibody response after challenge with pig tissue. The pathogenicity of anti-Neu5Gc antibody in xenotransplantation is not clear however as non-human transplant models, critical for modelling anti-Gal immunity, do not produce anti-Neu5Gc antibody. Antibody induced after xenotransplantation in non-human primates is directed to an array of pig endothelial cells proteins and to a glycan produced by the pig B4GALNT2 gene. We anticipate that immune suppression will significantly affect the T-cell dependent and independent specificity of an induced antibody response and that donor pigs deficient in synthesis of multiple xenogeneic glycans will be important to future studies. Twit Text FOAVip Recent Investigations into Pig Antigen and Anti-Pig Antibody Expression ????Int J Surg http://www.kidney.de/pget.php?&tw=1&pmid=26306769 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26306769 #FOAvip English Wikipedia <ref>{{Cite pmid|26306769}}</ref> Recent Investigations into Pig Antigen and Anti-Pig Antibody Expression #MMPMID26306769 Byrne GW; McGregor CG; Breimer ME Int J Surg 2015[Nov]; 23 (0 0): 223-8 PMID26306769show ga Genetic engineering of donor pigs to eliminate expression of the dominant xenogeneic antigen galactose ?1,3 galactose (Gal) has created a sea change in the immunobiology of xenograft rejection. Antibody mediated xenograft rejection of GGTA-1 ?-galactosyltransferase (GTKO) deficient organs is now directed to a combination of non-Gal pig protein and carbohydrate antigens. Glycan analysis of GTKO tissues identified no new neo-antigens but detected high levels of N-acetylneuraminic acid (Neu5Gc) modified glycoproteins and glycolipids. Humans produce anti-Neu5Gc antibody and in very limited clinical studies sometimes show an induced anti-Neu5Gc antibody response after challenge with pig tissue. The pathogenicity of anti-Neu5Gc antibody in xenotransplantation is not clear however as non-human transplant models, critical for modelling anti-Gal immunity, do not produce anti-Neu5Gc antibody. Antibody induced after xenotransplantation in non-human primates is directed to an array of pig endothelial cells proteins and to a glycan produced by the pig B4GALNT2 gene. We anticipate that immune suppression will significantly affect the T-cell dependent and independent specificity of an induced antibody response and that donor pigs deficient in synthesis of multiple xenogeneic glycans will be important to future studies. äRecent Investigations into Pig Antigen and Anti-Pig Antibody Expressio(epmc).pdf DeepDyve Pubget Overpricing