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10.1093/nutrit/nuv058

http://scihub22266oqcxt.onion/10.1093/nutrit/nuv058
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suck abstract from ncbi


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pmid26578625      Nutr+Rev 2016 ; 74 (1): 48-58
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  • Carbohydrate malabsorption in acutely malnourished children and infants: a systematic review #MMPMID26578625
  • Kvissberg MA; Dalvi PS; Kerac M; Voskuijl W; Berkley JA; Priebe MG; Bandsma RH
  • Nutr Rev 2016[Jan]; 74 (1): 48-58 PMID26578625show ga
  • Context: Severe acute malnutrition (SAM) accounts for approximately 1 million child deaths per year. High mortality is linked with comorbidities, such as diarrhea and pneumonia. Objective: The aim of this systematic review was to determine the extent to which carbohydrate malabsorption occurs in children with SAM. Data Sources: The PubMed and Embase databases were searched. Reference lists of selected articles were checked. Data Extraction: All observational and controlled intervention studies involving children with SAM in which direct or indirect measures of carbohydrate absorption were analyzed were eligible for inclusion. A total of 20 articles were selected for this review. Data Synthesis: Most studies reported carbohydrate malabsorption, particularly lactose malabsorption, and suggested an increase in diarrhea and reduced weight gain in children on a lactose-containing diet. As most studies reviewed were observational, there was no conclusive scientific evidence of a causal relationship between lactose malabsorption and a worse clinical outcome among malnourished children. Conclusion: The combined data indicate that carbohydrate malabsorption is prevalent in children with SAM. Additional well-designed intervention studies are needed to determine whether outcomes of SAM complicated by carbohydrate malabsorption could be improved by altering the carbohydrate/lactose content of therapeutic feeds and to elucidate the precise mechanisms involved.
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