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10.1093/annonc/mdv504 http://scihub22266oqcxt.onion/10.1093/annonc/mdv504 C4684158!4684158 !26489444     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26489444 &cmd=llinks): Failed to open stream: HTTP request failed! 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Treatment patterns and clinical outcomes in patients with renal cell carcinoma in the UK: insights from the RECCORD registry |pdf=|usr=}}{{26489444 }} gab.com Text Treatment patterns and clinical outcomes in patients with renal cell carcinoma in the UK: insights from the RECCORD registry JO: Ann Oncol http://www.kidney.de/pget.php?&tw=1&pmid=26489444 #FOAvip BACKGROUND: The aim of the RECCORD registry was to gather real-world UK data on the use of targeted therapies in renal cell carcinoma (RCC) and assess clinical outcomes. Here, demographic and outcome data are presented with the treatment patterns and demographic profile of patients on the registry. PATIENTS AND METHODS: Patients were retrospectively identified at seven UK hospitals with large cancer centres in England (5), Scotland (1) and Wales (1). Anonymised data were collected through an online registry covering demographics, treatments and outcomes. Five hundred and fourteen UK adult patients with metastatic RCC were included in the study for analysis. Patients were included if they were treated for metastatic RCC at one of the seven centres, and started systemic anti-cancer treatment from March 2009 to November 2012 inclusive. In addition to demographic factors, the principal outcome measures were overall survival (OS), time to disease progression and toxicity. RESULTS: The majority of first-line treatment was with sunitinib; first-line use of pazopanib increased as the study progressed. 15.8% of patients received second-line treatment, half of whom were prescribed everolimus. Median OS (from initiation of first-line treatment) was 23.9 months (95% confidence interval [CI] 18.6-29.1 months), similar to that reported for clinical trials of targeted RCC therapies [Ljungberg B, Campbell SC, Choi HY et al. The epidemiology of renal cell carcinoma. Eur Urol 2011; 60: 615-621; Abe H, Kamai T. Recent advances in the treatment of metastatic renal cell carcinoma. Int J Urol 2013; 20: 944-955; Motzer RJ, Hutson TE, Tomczak P et al. Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J Clin Oncol 2009; 27: 3584-3590]. OS was significantly longer for those who received second-line treatment after disease progression (33.0 months; 95% CI 30.8-35.2 months) than those who did not (20.9 months; 95% CI 16.4-25.3 months; P = 0.008). CONCLUSIONS: RECCORD is a large 'real-world' database assessing metastatic RCC treatment patterns and outcomes. Treatment patterns changed over time as targeted therapies were approved and became widely available; survival data in RECCORD are consistent with those reported for systemic treatments in clinical trials. Kaplan-Meier analysis of results demonstrated that receiving second-line therapy was a major prognostic factor for longer OS. Twit Text FOAVip Treatment patterns and clinical outcomes in patients with renal cell carcinoma in the UK: insights from the RECCORD registry ????Ann Oncol http://www.kidney.de/pget.php?&tw=1&pmid=26489444 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26489444 #FOAvip English Wikipedia <ref>{{Cite pmid|26489444 }}</ref> Treatment patterns and clinical outcomes in patients with renal cell carcinoma in the UK: insights from the RECCORD registry #MMPMID26489444 Wagstaff J ; Jones R ; Hawkins R ; Porfiri E ; Pickering L ; Bahl A ; Brown J ; Buchan S Ann Oncol 2016[Jan]; 27 (1 ): 159-65 PMID26489444 show ga BACKGROUND: The aim of the RECCORD registry was to gather real-world UK data on the use of targeted therapies in renal cell carcinoma (RCC) and assess clinical outcomes. Here, demographic and outcome data are presented with the treatment patterns and demographic profile of patients on the registry. PATIENTS AND METHODS: Patients were retrospectively identified at seven UK hospitals with large cancer centres in England (5), Scotland (1) and Wales (1). Anonymised data were collected through an online registry covering demographics, treatments and outcomes. Five hundred and fourteen UK adult patients with metastatic RCC were included in the study for analysis. Patients were included if they were treated for metastatic RCC at one of the seven centres, and started systemic anti-cancer treatment from March 2009 to November 2012 inclusive. In addition to demographic factors, the principal outcome measures were overall survival (OS), time to disease progression and toxicity. RESULTS: The majority of first-line treatment was with sunitinib; first-line use of pazopanib increased as the study progressed. 15.8% of patients received second-line treatment, half of whom were prescribed everolimus. Median OS (from initiation of first-line treatment) was 23.9 months (95% confidence interval [CI] 18.6-29.1 months), similar to that reported for clinical trials of targeted RCC therapies [Ljungberg B, Campbell SC, Choi HY et al. The epidemiology of renal cell carcinoma. Eur Urol 2011; 60: 615-621; Abe H, Kamai T. Recent advances in the treatment of metastatic renal cell carcinoma. Int J Urol 2013; 20: 944-955; Motzer RJ, Hutson TE, Tomczak P et al. Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J Clin Oncol 2009; 27: 3584-3590]. OS was significantly longer for those who received second-line treatment after disease progression (33.0 months; 95% CI 30.8-35.2 months) than those who did not (20.9 months; 95% CI 16.4-25.3 months; P = 0.008). CONCLUSIONS: RECCORD is a large 'real-world' database assessing metastatic RCC treatment patterns and outcomes. Treatment patterns changed over time as targeted therapies were approved and became widely available; survival data in RECCORD are consistent with those reported for systemic treatments in clinical trials. Kaplan-Meier analysis of results demonstrated that receiving second-line therapy was a major prognostic factor for longer OS. |Aged [MESH] |Angiogenesis Inhibitors/*therapeutic use [MESH] |Carcinoma, Renal Cell/*drug therapy/mortality/secondary [MESH] |Disease Progression [MESH] |Female [MESH] |Humans [MESH] |Indazoles [MESH] |Indoles/*therapeutic use [MESH] |Interferon-alpha/*therapeutic use [MESH] |Kaplan-Meier Estimate [MESH] |Kidney Neoplasms/*drug therapy/mortality/pathology [MESH] |Male [MESH] |Middle Aged [MESH] |Pyrimidines/*therapeutic use [MESH] |Pyrroles/*therapeutic use [MESH] |Registries [MESH] |Retrospective Studies [MESH] |Sulfonamides/*therapeutic use [MESH] |Sunitinib [MESH] |Treatment Outcome [MESH]Treatment patterns and clinical outcomes in patients with renal cell c(epmc).pdf DeepDyve Pubget Overpricing