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2015 ; 37
(6
): 657-65
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A meiotic mystery: How sister kinetochores avoid being pulled in opposite
directions during the first division
#MMPMID25874377
Nasmyth K
Bioessays
2015[Jun]; 37
(6
): 657-65
PMID25874377
show ga
We now take for granted that despite the disproportionate contribution of females
to initial growth of their progeny, there is little or no asymmetry in the
contribution of males and females to the eventual character of their shared
offspring. In fact, this key insight was only established towards the end of the
eighteenth century by Joseph Koelreuter's pioneering plant breeding experiments.
If males and females supply equal amounts of hereditary material, then the latter
must double each time an embryo is conceived. How then does the amount of this
mysterious stuff not multiply exponentially from generation to generation? A
compensatory mechanism for diluting the hereditary material must exist, one that
ensures that if each parent contributes one half, each grandparent contributes a
quarter, and each great grandparent merely an eighth. An important piece of the
puzzle of how hereditary material is diluted at each generation has been
elucidated over the past ten years.