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10.1002/bies.201500020 http://scihub22266oqcxt.onion/10.1002/bies.201500020 C4683672!4683672!25988527     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Bioessays 2015 ; 37 (7): 755-66 Nephropedia Template TP {{tp|p=25988527|t=2015. Shaping mitotic chromosomes: From classical concepts to molecular mechanisms |pdf=|usr=}}{{25988527}} gab.com Text Shaping mitotic chromosomes: From classical concepts to molecular mechanisms JO: Bioessays http://www.kidney.de/pget.php?&tw=1&pmid=25988527 #FOAvip How eukaryotic genomes are packaged into compact cylindrical chromosomes in preparation for cell divisions has remained one of the major unsolved questions of cell biology. Novel approaches to study the topology of DNA helices inside the nuclei of intact cells, paired with computational modeling and precise biomechanical measurements of isolated chromosomes, have advanced our understanding of mitotic chromosome architecture. In this Review Essay, we discuss ? in light of these recent insights ? the role of chromatin architecture and the functions and possible mechanisms of SMC protein complexes and other molecular machines in the formation of mitotic chromosomes. Based on the information available, we propose a stepwise model of mitotic chromosome condensation that envisions the sequential generation of intra-chromosomal linkages by condensin complexes in the context of cohesin-mediated inter-chromosomal linkages, assisted by topoisomerase II. The described scenario results in rod-shaped metaphase chromosomes ready for their segregation to the cell poles. Twit Text FOAVip Shaping mitotic chromosomes: From classical concepts to molecular mechanisms ????Bioessays http://www.kidney.de/pget.php?&tw=1&pmid=25988527 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25988527 #FOAvip English Wikipedia <ref>{{Cite pmid|25988527}}</ref> Shaping mitotic chromosomes: From classical concepts to molecular mechanisms #MMPMID25988527 Kschonsak M; Haering CH Bioessays 2015[Jul]; 37 (7): 755-66 PMID25988527show ga How eukaryotic genomes are packaged into compact cylindrical chromosomes in preparation for cell divisions has remained one of the major unsolved questions of cell biology. Novel approaches to study the topology of DNA helices inside the nuclei of intact cells, paired with computational modeling and precise biomechanical measurements of isolated chromosomes, have advanced our understanding of mitotic chromosome architecture. In this Review Essay, we discuss ? in light of these recent insights ? the role of chromatin architecture and the functions and possible mechanisms of SMC protein complexes and other molecular machines in the formation of mitotic chromosomes. Based on the information available, we propose a stepwise model of mitotic chromosome condensation that envisions the sequential generation of intra-chromosomal linkages by condensin complexes in the context of cohesin-mediated inter-chromosomal linkages, assisted by topoisomerase II. The described scenario results in rod-shaped metaphase chromosomes ready for their segregation to the cell poles. äShaping mitotic chromosomes: From classical concepts to molecular mech(epmc).pdf DeepDyve Pubget Overpricing