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10.1038/srep18491 http://scihub22266oqcxt.onion/10.1038/srep18491 C4683439!4683439 !26677948     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26677948 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2015 ; 5 (ä): 18491 Nephropedia Template TP {{tp|p=26677948 |t=2015. Kindlin-3 interacts with the ribosome and regulates c-Myc expression required for proliferation of chronic myeloid leukemia cells |pdf=|usr=}}{{26677948 }} gab.com Text Kindlin-3 interacts with the ribosome and regulates c-Myc expression required for proliferation of chronic myeloid leukemia cells JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26677948 #FOAvip Kindlins are FERM-containing cytoplasmic proteins that regulate integrin-mediated cell-cell and cell-extracellular matrix (ECM) attachments. Kindlin-3 is expressed in hematopoietic cells, platelets, and endothelial cells. Studies have shown that kindlin-3 stabilizes cell adhesion mediated by ß1, ß2, and ß3 integrins. Apart from integrin cytoplasmic tails, kindlins are known to interact with other cytoplasmic proteins. Here we demonstrate that kindlin-3 can associate with ribosome via the receptor for activated-C kinase 1 (RACK1) scaffold protein based on immunoprecipitation, ribosome binding, and proximity ligation assays. We show that kindlin-3 regulates c-Myc protein expression in the human chronic myeloid leukemia cell line K562. Cell proliferation was reduced following siRNA reduction of kindlin-3 expression and a significant reduction in tumor mass was observed in xenograft experiments. Mechanistically, kindlin-3 is involved in integrin ?5ß1-Akt-mTOR-p70S6K signaling; however, its regulation of c-Myc protein expression could be independent of this signaling axis. Twit Text FOAVip Kindlin-3 interacts with the ribosome and regulates c-Myc expression required for proliferation of chronic myeloid leukemia cells ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26677948 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26677948 #FOAvip English Wikipedia <ref>{{Cite pmid|26677948 }}</ref> Kindlin-3 interacts with the ribosome and regulates c-Myc expression required for proliferation of chronic myeloid leukemia cells #MMPMID26677948 Qu J ; Ero R ; Feng C ; Ong LT ; Tan HF ; Lee HS ; Ismail MH ; Bu WT ; Nama S ; Sampath P ; Gao YG ; Tan SM Sci Rep 2015[Dec]; 5 (ä): 18491 PMID26677948 show ga Kindlins are FERM-containing cytoplasmic proteins that regulate integrin-mediated cell-cell and cell-extracellular matrix (ECM) attachments. Kindlin-3 is expressed in hematopoietic cells, platelets, and endothelial cells. Studies have shown that kindlin-3 stabilizes cell adhesion mediated by ß1, ß2, and ß3 integrins. Apart from integrin cytoplasmic tails, kindlins are known to interact with other cytoplasmic proteins. Here we demonstrate that kindlin-3 can associate with ribosome via the receptor for activated-C kinase 1 (RACK1) scaffold protein based on immunoprecipitation, ribosome binding, and proximity ligation assays. We show that kindlin-3 regulates c-Myc protein expression in the human chronic myeloid leukemia cell line K562. Cell proliferation was reduced following siRNA reduction of kindlin-3 expression and a significant reduction in tumor mass was observed in xenograft experiments. Mechanistically, kindlin-3 is involved in integrin ?5ß1-Akt-mTOR-p70S6K signaling; however, its regulation of c-Myc protein expression could be independent of this signaling axis. |Animals [MESH] |Antibiotics, Antineoplastic/pharmacology [MESH] |Cell Proliferation/drug effects [MESH] |GTP-Binding Proteins/metabolism [MESH] |HEK293 Cells [MESH] |Human Umbilical Vein Endothelial Cells [MESH] |Humans [MESH] |Integrin beta3/metabolism [MESH] |K562 Cells [MESH] |Leukemia, Myelogenous, Chronic, BCR-ABL Positive/metabolism/pathology [MESH] |Membrane Proteins/antagonists & inhibitors/genetics/*metabolism [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Mice, Knockout [MESH] |Neoplasm Proteins/antagonists & inhibitors/genetics/*metabolism [MESH] |Protein Binding [MESH] |Proto-Oncogene Proteins c-myc/genetics/*metabolism [MESH] |RNA Interference [MESH] |Receptors for Activated C Kinase [MESH] |Receptors, Cell Surface/metabolism [MESH] |Recombinant Proteins/biosynthesis/chemistry/isolation & purification [MESH] |Ribosomes/*metabolism [MESH] |Signal Transduction/drug effects [MESH] |Sirolimus/pharmacology [MESH]Kindlin-3 interacts with the ribosome and regulates c-Myc expression r(epmc).pdf DeepDyve Pubget Overpricing