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10.1038/srep18233 http://scihub22266oqcxt.onion/10.1038/srep18233 C4683370!4683370 !26678431     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26678431 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2015 ; 5 (ä): 18233 Nephropedia Template TP {{tp|p=26678431 |t=2015. Transforming Growth Factor-?1 Induced Epithelial Mesenchymal Transition is blocked by a chemical antagonist of translation factor eIF4E |pdf=|usr=}}{{26678431 }} gab.com Text Transforming Growth Factor- 1 Induced Epithelial Mesenchymal Transition is blocked by a chemical antagonist of translation factor eIF4E JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26678431 #FOAvip The epithelial to mesenchymal transition (EMT) imparts disease-defining properties to epithelial cells in cancer and organ fibrosis. Prior studies identify EMT control points at the level of transcription and translation, and indicate that activation of translation initiation factor 4E (eIF4E) is involved in the mechanisms coordinating these two levels of control. Here we show that 4Ei-1, a specific chemical antagonist of the eIF4E-mRNA cap interaction, potently inhibits transforming growth factor beta 1 (TGF-?1) mediated EMT in lung epithelial cells. Upon treatment with TGF-?1, we observed a rapid recruitment of Snail1 mRNA into the actively translated polysome pool accompanied by accumulation of the EMT transcription factor Snail1 in the nucleus. 4Ei-1 blocks ribosome recruitment to the Snail1 transcript thereby preventing accumulation of the Snail1 protein in the nucleus. Our findings establish an obligatory role for upstream translational control of downstream Snail1-mediated transcriptional events in TGF-?1 induced EMT, and provide proof of concept for efforts to pharmacologically modulate the eIF4E-cap interaction as a means to inhibit pathological EMT in the setting of cancer and organ fibrosis. Twit Text FOAVip Transforming Growth Factor- 1 Induced Epithelial Mesenchymal Transition is blocked by a chemical antagonist of translation factor eIF4E ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26678431 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26678431 #FOAvip English Wikipedia <ref>{{Cite pmid|26678431 }}</ref> Transforming Growth Factor-?1 Induced Epithelial Mesenchymal Transition is blocked by a chemical antagonist of translation factor eIF4E #MMPMID26678431 Smith KA ; Zhou B ; Avdulov S ; Benyumov A ; Peterson M ; Liu Y ; Okon A ; Hergert P ; Braziunas J ; Wagner CR ; Borok Z ; Bitterman PB Sci Rep 2015[Dec]; 5 (ä): 18233 PMID26678431 show ga The epithelial to mesenchymal transition (EMT) imparts disease-defining properties to epithelial cells in cancer and organ fibrosis. Prior studies identify EMT control points at the level of transcription and translation, and indicate that activation of translation initiation factor 4E (eIF4E) is involved in the mechanisms coordinating these two levels of control. Here we show that 4Ei-1, a specific chemical antagonist of the eIF4E-mRNA cap interaction, potently inhibits transforming growth factor beta 1 (TGF-?1) mediated EMT in lung epithelial cells. Upon treatment with TGF-?1, we observed a rapid recruitment of Snail1 mRNA into the actively translated polysome pool accompanied by accumulation of the EMT transcription factor Snail1 in the nucleus. 4Ei-1 blocks ribosome recruitment to the Snail1 transcript thereby preventing accumulation of the Snail1 protein in the nucleus. Our findings establish an obligatory role for upstream translational control of downstream Snail1-mediated transcriptional events in TGF-?1 induced EMT, and provide proof of concept for efforts to pharmacologically modulate the eIF4E-cap interaction as a means to inhibit pathological EMT in the setting of cancer and organ fibrosis. |Actins/metabolism [MESH] |Animals [MESH] |Cell Line [MESH] |Cell Nucleus/metabolism [MESH] |Epithelial Cells/cytology/metabolism [MESH] |Epithelial-Mesenchymal Transition/*drug effects [MESH] |Eukaryotic Initiation Factor-4E/*antagonists & inhibitors/genetics/metabolism [MESH] |Guanosine Monophosphate/analogs & derivatives/pharmacology [MESH] |Lamin Type A/metabolism [MESH] |Microscopy, Fluorescence [MESH] |RNA Interference [MESH] |RNA, Messenger/metabolism [MESH] |RNA, Small Interfering/metabolism [MESH] |Rats [MESH] |Snail Family Transcription Factors [MESH] |Transcription Factors/metabolism [MESH]Transforming Growth Factor-?1 Induced Epithelial Mesenchymal Transitio(epmc).pdf DeepDyve Pubget Overpricing