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10.1182/blood-2015-09-668962

http://scihub22266oqcxt.onion/10.1182/blood-2015-09-668962
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C4683328!4683328!26679542
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suck abstract from ncbi

pmid26679542      Blood 2015 ; 126 (25): 2658-9
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  • The Rap1-RIAM pathway prefers ?2 integrins #MMPMID26679542
  • Calderwood DA
  • Blood 2015[Dec]; 126 (25): 2658-9 PMID26679542show ga
  • In vitro studies strongly implicate the talin-binding Ras-related protein 1 (Rap1) effector, Rap1-guanosine triphosphate?interacting adapter molecule (RIAM), in integrin activation.1 Yet, the RIAM knockout mouse is viable and fertile and exhibits no platelet adhesion or aggregation defects,2 casting doubt on the in vivo role of RIAM. In this issue of Blood, Su et al3 and Klapproth et al4 now show that RIAM is required for ?2 integrin?dependent leukocyte adhesion and trafficking in vitro and in vivo, but apparently not for all Rap- and talin-meditated activation of ?1 and ?3 integrins.
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