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2015 ; 3
(6
): E605-9
Nephropedia Template TP
gab.com Text
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English Wikipedia
Early clinical experience of the safety and efficacy of EndoClot in the
management of non-variceal upper gastrointestinal bleeding
#MMPMID26716120
Beg S
; Al-Bakir I
; Bhuva M
; Patel J
; Fullard M
; Leahy A
Endosc Int Open
2015[Dec]; 3
(6
): E605-9
PMID26716120
show ga
BACKGROUND AND STUDY AIMS: EndoClot is a novel topical hemostatic powder approved
for use in non-variceal upper gastrointestinal bleeding. This study examines its
impact as rescue therapy in the management of gastrointestinal bleeding for which
standard endoscopic therapy failed to achieve hemostasis. METHODS: This
observational study covered a 24-month period. Data were collated from patients
treated with EndoClot for comparison with a cohort of patients managed with
standard endoscopic therapy. End points of this study included immediate
hemostasis, 30-day rebleed rate, 30-day mortality rate, and adverse events.
RESULTS: Between April 1, 2012, and March 31, 2014, gastroscopic procedures were
performed in 1009 patients, of whom 173 required endoscopic therapy. EndoClot was
used in 21 patients, with immediate hemostasis achieved in all cases, a 30-day
rebleed rate of 4.8?% (95?% confidence interval [95?%CI]?-?4.34?% to 3.94?%), and
a 30-day mortality rate of 19.0?% (95?%CI 2.29?%?-?35.91?%). Despite higher risk
bleeds in this cohort of patients, Fisher's exact test demonstrated no
significant difference between their 30-day mortality rate (P?=?0.51) and rebleed
rate (P?=?0.31) and those of the patients treated with standard endoscopic
hemostatic techniques. CONCLUSIONS: This study demonstrates that EndoClot can be
used both safely and effectively in the management of non-variceal upper
gastrointestinal bleeding.