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2015 ; 3
(6
): E590-6
Nephropedia Template TP
gab.com Text
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Twit Text #
English Wikipedia
A significant feature of microvessels in magnifying narrow-band imaging for
diagnosis of early gastric cancer
#MMPMID26716118
Kanesaka T
; Uedo N
; Yao K
; Ezoe Y
; Doyama H
; Oda I
; Kaneko K
; Kawahara Y
; Yokoi C
; Sugiura Y
; Ishikawa H
; Kato M
; Takeuchi Y
; Muto M
; Saito Y
Endosc Int Open
2015[Dec]; 3
(6
): E590-6
PMID26716118
show ga
BACKGROUND AND STUDY AIMS: Magnifying narrow-band imaging (NBI) is more useful
than conventional endoscopy for diagnosing early gastric cancer (EGC). However,
evaluation of irregular microvascular patterns is subjective and is often
difficult, even with expert eyes. The aim of this study was to clarify the most
important microvascular patterns in magnifying NBI for diagnosis of EGC. PATIENTS
AND METHODS: This was a post-hoc analysis of a multicenter prospective trial
among nine Japanese hospitals. A total of 1353 patients underwent screening with
white-light endoscopy and 362 patients had small (??10?mm) depressed lesions.
They were randomly assigned to magnifying NBI or white-light endoscopy followed
by magnifying NBI. During diagnosis, magnifying NBI images were recorded before
biopsy. All magnifying NBI images were reviewed and evaluated for the association
of four features of microvessels - that is, dilation, tortuosity, difference in
caliber, and variation in shape - with cancer diagnosis. RESULTS: Images of 343
lesions (40 cancerous and 303 benign depression lesions) were evaluable. The
diagnostic performance (sensitivity/specificity) of each finding was: dilation,
25/90?%; tortuosity, 55/24?%; difference in caliber, 13?/99?%; and variation in
shape, 70/95?%. Multivariate analysis identified only variation in shape as being
statistically significantly associated with diagnosis of cancer (odds ratio 38.0,
95?% confidence interval: 16.1?-?95.7, P?0.001). All findings showed moderate
agreement (? values): dilation, 0.44; tortuosity, 0.33; difference in caliber,
0.26; and variation in shape, 0.48. CONCLUSIONS: A variation in shape was the
most significant feature of microvessels observed in magnifying NBI for diagnosis
of small depressed-type EGC. STUDY REGISTRATION: UMIN-CTR000001072.